The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs

    Jessica Stahl, Frank Niedorf, Mareike Wohlert, Manfred Kietzmann
    Studysummary This study found that caffeine and flufenamic acid penetrated porcine skin more effectively through hair follicles, while the importance of the follicular pathway varied for other substances tested.
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    Research cited in this study 5

    1. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    2. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    3. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    4. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    5. Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro Journal of drug targeting · 2002

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    2. Effects of TNF-Alpha and Minoxidil on Human Hair Growth In Vitro Journal of Clinical Dermatology · 2003
    3. KF19418, A New Compound for Hair Growth Promotion in Vitro and in Vivo Mouse Models Journal of Dermatological Science · 2001
    4. Effect of Minoxidil on Cultured Human Hair Follicle Cells Journal of Dermatological Science · 1990
    5. Sulfation of Minoxidil in Keratinocytes and Hair Follicles PubMed · 1989