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research An open-access data set of pig skin anatomy and physiology for modelling purposes

6 citations , January 2022 in “Database”

This database provides detailed physiological parameters of porcine skin to enhance the MPML MechDermA Model, improving dermal absorption predictions for human studies in the Simcyp Simulator.

research Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig.,

45 citations , August 1954 in “Experimental Biology and Medicine”

This study found that vitamin A dissolved in alcohol penetrates skin quickly and does not impair hair growth, even in large doses, but it does not retard keratinization unlike when dissolved in fatty acids.

research Rejuvenation of Aged Pig Facial Skin by Transplanting Allogeneic Granulocyte Colony-Stimulating Factor-Induced Peripheral Blood Stem Cells from a Young Pig

8 citations , March 2013 in “Cell Transplantation”

In this study, intradermal injection of GCSF-mobilized peripheral blood stem cells from young pigs rejuvenated skin in aged pigs by increasing collagen, elastin, and cell renewal rates.

Effect of Deep Dermal Tissue Dislocation Injury on Skin Fibrosis in Pigs

research [Effect of deep dermal tissue dislocation injury on skin fibrosis in pig].

November 2022 in “PubMed”

This study found that inadequate thickness of deep dermal tissue in pigs is a key factor leading to fibrosis, with fibrosis likely serving a compensatory function for skin thickness.

Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

38 citations , June 2018 in “Archives of Toxicology”

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

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Community Join

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community Eye bags from topical minoxidil — what actually worked for you?

6 upvotes 1 week ago

Minoxidil can cause under-eye bags due to fluid retention, and some users find relief by stopping its use or switching to oral forms. Collagen supplements, reducing sodium intake, and using skincare products like eye creams and sunscreen may help improve the appearance of eye bags.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Has anyone used verteporfin + microneedling?

10 upvotes 2 years ago

A user is considering using verteporfin with microneedling, oral/topical minoxidil, and RU58841 to treat hair loss. They seek advice on dosage and application methods.

community questions regarding topical finasteride

in Finasteride 4 upvotes 7 years ago

The conversation discusses the potential effectiveness and risks of using topical finasteride for hair loss, with considerations about using DMSO as a vehicle for application. Concerns are raised about DMSO's safety, absorption issues, and the systemic effects of topical finasteride.

community Red Light Therapy: Cheap Chinese LED caps are better than $3000 laser caps

in Research/Science 37 upvotes 1 year ago

Affordable 92-LED caps may be more effective for hair growth than expensive 270-laser caps due to higher power output and irradiance. The LED caps deliver more energy to the scalp, making them a cost-effective alternative for red light therapy.

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