Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

June 2010 in “ European Journal of Pharmaceutics and Biopharmaceutics ”

Ulrike Blume-Peytavi, L Massoudy, Alexa Patzelt, Jürgen Lademann, Ekkehart Dietz, Utkur Rasulev, Natalie Garcia Bartels

minoxidil hair follicles topically applied substances interfollicular epidermis skin barrier function Rogaine

Studysummary This study found that hair follicles are a significant and efficient pathway for the absorption of topical minoxidil foam in humans, with faster blood detection when follicles are open.

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This study investigated the penetration pathways of topically applied minoxidil foam for hair growth. The study found that hair follicles are an efficient penetration pathway and reservoir for topically applied substances. The study concluded that minoxidil can penetrate through both the hair follicle and the interfollicular epidermis. The authors suggest that understanding the follicular penetration of drugs will lead to better drug delivery and a better understanding of skin barrier function.

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Research cited in this study

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research In Vitro and In Vivo Study of Dye Diffusion into Human Skin and Hair Follicles

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