Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

January 2018 in “ Pharmaceutics ”

Eman Abd, Heather A. E. Benson, Michael S. Roberts, Jeffrey E. Grice

minoxidil nanoemulsion eucalyptol oleic acid hair follicles surfactant co-surfactant phosphate buffered saline Rogaine

From the encyclopedia

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that nanoemulsions incorporating skin penetration enhancers significantly increased the permeation of minoxidil through human skin compared to aqueous control solutions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A study from 5 years ago found that nanoemulsion formulations containing eucalyptol or oleic acid can improve the delivery of minoxidil to hair follicles, potentially enhancing its effectiveness in treating hair loss. Eucalyptol retained minoxidil in deeper skin layers, while oleic acid had the greatest hair follicle penetration. The study aimed to improve the delivery of minoxidil to hair follicles by developing and testing nanoemulsion formulations containing eucalyptol or oleic acid. The formulations were clear and contained surfactant, co-surfactant, and phosphate buffered saline. Minoxidil was dissolved in the nanoemulsion and control solutions. However, further research is needed to confirm these findings in vivo.

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