Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

January 2018 in “ Pharmaceutics ”

Eman Abd, Heather A. E. Benson, Michael S. Roberts, Jeffrey E. Grice

minoxidil nanoemulsion eucalyptol oleic acid hair follicles surfactant co-surfactant phosphate buffered saline Rogaine

TLDR Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.

A study from 5 years ago found that nanoemulsion formulations containing eucalyptol or oleic acid can improve the delivery of minoxidil to hair follicles, potentially enhancing its effectiveness in treating hair loss. Eucalyptol retained minoxidil in deeper skin layers, while oleic acid had the greatest hair follicle penetration. The study aimed to improve the delivery of minoxidil to hair follicles by developing and testing nanoemulsion formulations containing eucalyptol or oleic acid. The formulations were clear and contained surfactant, co-surfactant, and phosphate buffered saline. Minoxidil was dissolved in the nanoemulsion and control solutions. However, further research is needed to confirm these findings in vivo.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

48 citations, January 2017 in “Skin Pharmacology and Physiology”

Finasteride-loaded nanoparticles may help treat alopecia.

research Human Hair Follicle: Reservoir Function and Selective Targeting

97 citations, September 2011 in “British Journal of Dermatology”

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

research Transcutol-Containing Vesicles for Topical Delivery of Minoxidil

51 citations, May 2010 in “Journal of Drug Targeting”

Transcutol-containing vesicles improve minoxidil's skin penetration and hair growth promotion.

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

55 citations, June 2009 in “Journal of Pharmaceutical Sciences”

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

268 citations, April 2009 in “International Journal of Pharmaceutics”

Niosomes improve minoxidil skin delivery for hair loss treatment.

research Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions

33 citations, February 2009 in “European journal of pharmaceutics and biopharmaceutics”

Pig ear skin is better than human skin for testing how well barrier creams block allergens from entering hair follicles.

research Comparison of Stratum Corneum Penetration and Localization of a Lipophilic Model Drug Applied in an O/W Microemulsion and an Amphiphilic Cream

132 citations, April 2007 in “European journal of pharmaceutics and biopharmaceutics”

The microemulsion delivered the dye deeper into the skin than the cream.

research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

85 citations, January 2007 in “Journal of Drug Targeting”

Liposomes better deliver minoxidil for hair loss treatment than niosomes.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations, August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The new "differential stripping" method effectively measures how much substance gets into hair follicles.

research Penetration and Distribution of Three Lipophilic Probes in Human Skin Focusing on the Hair Follicle

54 citations, October 2002 in “Journal of controlled release”

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

Related Research

2 / 2 results

Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

research Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

40 citations, January 2018 in “Pharmaceutics”

Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.

Analysis of the Pretreatment Effect of Ethanol on the Stratum Corneum and Hair Follicular Penetration of Drugs Using the Hair Follicle Plugging Method

research Analysis of the Pretreatment Effect of Ethanol on the Stratum Corneum and Hair Follicular Penetration of Drugs Using the Hair Follicle Plugging Method

10 citations, January 2014 in “Chemical and Pharmaceutical Bulletin”

Ethanol pretreatment affects drug penetration through skin and hair follicles.

Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

Research cited in this study

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

research Human Hair Follicle: Reservoir Function and Selective Targeting

research Transcutol-Containing Vesicles for Topical Delivery of Minoxidil

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

research Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions

research Comparison of Stratum Corneum Penetration and Localization of a Lipophilic Model Drug Applied in an O/W Microemulsion and an Amphiphilic Cream

research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

research Penetration and Distribution of Three Lipophilic Probes in Human Skin Focusing on the Hair Follicle

Related Community Posts Join

community Study shows significant improvement in hair with topical minoxidil and oral Vitamin d compared to just topical minoxidil alone.

community Studies on Minoxidil show an increase in hair count shortly after starting treatment

community Why is Minoxidil not enough for hair loss? (No fin)

community How to ease off oral minoxidil?

community Is there any true alternatives to minoxidil that doesn't effect heartrate?

community Minoxidil doing wonders already

Related Research

research Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

research Analysis of the Pretreatment Effect of Ethanol on the Stratum Corneum and Hair Follicular Penetration of Drugs Using the Hair Follicle Plugging Method