Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

January 2018 in “ Pharmaceutics ”

Eman Abd, Heather A. E. Benson, Michael S. Roberts, Jeffrey E. Grice

minoxidil nanoemulsion eucalyptol oleic acid hair follicles surfactant co-surfactant phosphate buffered saline Rogaine

TLDR Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.

A study from 5 years ago found that nanoemulsion formulations containing eucalyptol or oleic acid can improve the delivery of minoxidil to hair follicles, potentially enhancing its effectiveness in treating hair loss. Eucalyptol retained minoxidil in deeper skin layers, while oleic acid had the greatest hair follicle penetration. The study aimed to improve the delivery of minoxidil to hair follicles by developing and testing nanoemulsion formulations containing eucalyptol or oleic acid. The formulations were clear and contained surfactant, co-surfactant, and phosphate buffered saline. Minoxidil was dissolved in the nanoemulsion and control solutions. However, further research is needed to confirm these findings in vivo.

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Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

research Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

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Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.

research Analysis of the Pretreatment Effect of Ethanol on the Stratum Corneum- and Hair Follicular-Penetration of Drugs Using the Hair Follicle-Plugging Method

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Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

Research cited in this study

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

research Human Hair Follicle: Reservoir Function and Selective Targeting

research Transcutol-Containing Vesicles for Topical Delivery of Minoxidil

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

research Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions

research Comparison of Stratum Corneum Penetration and Localization of a Lipophilic Model Drug Applied in an O/W Microemulsion and an Amphiphilic Cream

research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

research Penetration and Distribution of Three Lipophilic Probes in Human Skin Focusing on the Hair Follicle

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