Retinoids: Compounds Important to Hair Growth

    October 1988 in “ Clinics in dermatology ”
    Nia Terezakis, Gaetano Bazzano
    TLDR Retinoids might help hair grow and improve hair loss treatments.
    The document discussed the potential role of retinoids in hair growth, particularly in the context of androgenetic alopecia. Although the exact mechanisms were not fully understood, retinoids were observed to possibly reverse epithelial dysplastic changes and influence hair follicle dynamics. Preliminary studies suggested that retinoids might increase hair growth rates, extend the anagen phase, convert vellus hairs to terminal hairs, and work synergistically with minoxidil to enhance hair regrowth. The authors recommended larger controlled studies and improved methods for assessing hair growth to validate these early findings and explore other retinoids and minoxidil analogs.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 2 years ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

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