Retinoids: Compounds Important to Hair Growth

October 1988 in “ Clinics in dermatology ”

Nia Terezakis, Gaetano Bazzano

retinoids androgenetic alopecia epithelial dysplastic changes hair follicle dynamics anagen phase vellus hairs terminal hairs minoxidil minoxidil analogs Rogaine

TLDR Retinoids might help hair grow and improve hair loss treatments.

The document discussed the potential role of retinoids in hair growth, particularly in the context of androgenetic alopecia. Although the exact mechanisms were not fully understood, retinoids were observed to possibly reverse epithelial dysplastic changes and influence hair follicle dynamics. Preliminary studies suggested that retinoids might increase hair growth rates, extend the anagen phase, convert vellus hairs to terminal hairs, and work synergistically with minoxidil to enhance hair regrowth. The authors recommended larger controlled studies and improved methods for assessing hair growth to validate these early findings and explore other retinoids and minoxidil analogs.

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Research cited in this study

7 / 7 results

research Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia

24 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil 1% and 2% best promote hair growth and may prevent hair loss.

research Topical Tretinoin for Hair Growth Promotion

73 citations, October 1986 in “Journal of the American Academy of Dermatology”

Tretinoin may help hair growth and works better when combined with minoxidil.

research Topical Minoxidil Useful in 18% of Patients with Androgenetic Alopecia: A Study of 430 Cases

16 citations, July 1986 in “Dermatology”

Using minoxidil lotion for hair regrowth in androgenetic alopecia has limited success and should be evaluated carefully.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations, February 1986 in “Archives of Dermatology”

Higher minoxidil concentration (5%) works better for severe hair loss, with most patients seeing regrowth in 48-60 weeks.

research Allergic Contact Dermatitis to Minoxidil

29 citations, August 1985 in “Contact Dermatitis”

Minoxidil can cause allergic reactions like burning, itching, and red bumps.

research Monilethrix Treated with the Oral Retinoid Ro 10-9359 (Tigason)

24 citations, July 1983 in “Clinical and Experimental Dermatology”

Tigason improved hair growth in a boy with monilethrix without side effects.

research Oral Retinoids in Dermatology

52 citations, June 1981 in “International Journal of Dermatology”

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

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6 / 127 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 1 year ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Tretinoin can make it worse!!!

in Chat 7 upvotes 1 year ago

Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 96 upvotes 6 months ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

community Study: minoxidil alone is just as effective as minox+tretinoin+azelaic acid

in Research/Science 17 upvotes 3 years ago

Minoxidil alone is just as effective as when combined with tretinoin and azelaic acid for hair loss. People adding tretinoin and azelaic acid to minoxidil may not see the expected benefits.

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research KF19418, A New Compound for Hair Growth Promotion in Vitro and in Vivo Mouse Models

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