Investigation of Follicular and Non-Follicular Pathways for Polyarginine and Oleic Acid-Modified Nanoparticles

November 2012 in “ Pharmaceutical research ”

Pinaki R. Desai, Priyanka Shah, Patrick Hayden, Mandip Singh

cell penetrating peptide CPP lipid nanoparticles oleic acid polymeric nanoparticles ibuprofen epidermis dermis hair follicles allergic contact dermatitis inflammatory skin diseases

Studysummary This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The 2012 study investigated the skin permeation pathways of cell penetrating peptide (CPP) modified lipid nanoparticles and oleic acid modified polymeric nanoparticles. It was found that these surface-modified nanoparticles significantly increased the permeation of ibuprofen through the skin, with higher levels observed in the epidermis and dermis compared to controls. The hair follicles were determined to play a minor role in the permeation process, contributing less than 5%. The study also demonstrated that the modified nanoparticles were effective in treating allergic contact dermatitis, suggesting a potential for improved therapeutic responses in inflammatory skin diseases. The in vitro skin permeation studies involved sample sizes of n=6 for differential stripping and n=12 for permeation into the receiver compartment. The conclusion was that the increased skin permeation of surface-modified nanoparticles occurs through both follicular and non-follicular pathways, with non-follicular pathways being predominant.

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