Triggering of Drug Release of Particles in Hair Follicles

April 2012 in “ Journal of controlled release ”

Wing Cheung Mak, Alexa Patzelt, Heike Richter, Reinhardt Renneberg, Kwok Kei Lai, E. Rühl, Wolfram Sterry, Jürgen Lademann

hair follicles drug delivery mixed particle formulation drug carrier protease porcine skin sebaceous gland targeted treatment skin diseases

TLDR New method uses hair follicles to deliver drugs deep into the skin.

The study explored a novel method for drug delivery via hair follicles using a mixed particle formulation. Two types of particles of the same size were used: one as a drug carrier and the other loaded with a protease to trigger drug release. When applied to porcine skin samples, the protease successfully released the model drug from the carrier particles at significant depths within the hair follicle (866 ± 62 nm) and facilitated drug uptake in the sebaceous gland. This approach showed promise for developing targeted treatment strategies for various skin diseases.

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Research cited in this study

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Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

research Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

94 citations, May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.

research Penetration and Storage of Particles in Human Skin: Perspectives and Safety Aspects

122 citations, April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations, February 2011 in “Journal of Controlled Release”

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

research Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

74 citations, June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics”

Minoxidil foam enters hair follicles and skin for hair growth.

research Prevention of Follicular Penetration: Barrier-Enhancing Formulations Against the Penetration of Pollen Allergens into Hair Follicles

21 citations, January 2010 in “Skin pharmacology and physiology”

Special creams can significantly reduce pollen allergens getting into hair follicles.

research Hair Follicles, Their Disorders, and Their Opportunities

48 citations, May 2008 in “Drug Discovery Today: Disease Mechanisms”

Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.

research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

182 citations, December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations, April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations, June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

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research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations, August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.