Triggering of Drug Release of Particles in Hair Follicles

    April 2012 in “ Journal of controlled release ”
    Wing Cheung Mak, Alexa Patzelt, Heike Richter … Jürgen Lademann
    Studysummary This study found that using a protease-triggered release system enabled effective delivery of a model drug deep within porcine hair follicles, suggesting a new approach for treating skin conditions.
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    Research cited in this study 10

    1. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    2. Penetration and Storage of Particles in Human Skin: Perspectives and Safety Aspects European Journal of Pharmaceutics and Biopharmaceutics · 2011
    3. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    4. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    5. Prevention of Follicular Penetration: Barrier-Enhancing Formulations Against the Penetration of Pollen Allergens into Hair Follicles Skin pharmacology and physiology · 2010
    6. Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles Journal of Biomedical Optics · 2009
    7. Hair Follicles, Their Disorders, and Their Opportunities Drug Discovery Today: Disease Mechanisms · 2008
    8. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    9. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    10. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004

    Related research 1

    1. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001