TLDR Artificial sebum L closely mimics human sebum for drug delivery research.
The study developed an artificial sebum, named L, to investigate drug transport properties for hair and sebaceous follicles, comparing it with human sebum and hamster sebum, which is often used in animal models. The partition and diffusion of three model compounds were measured across human, hamster ear and body sebum, and four artificial sebum samples (N, S, F, and L). Differential Scanning Calorimetry (DSC) and Nuclear Magnetic Resonance (NMR) studies assessed the melting properties and chemical compositions of these sebum samples. The results showed that the partition coefficients and in vitro sebum flux of the model compounds in artificial sebum L were similar to those in human sebum, making it a suitable surrogate for human sebum in drug delivery studies. In contrast, the other artificial sebum samples (N, S, and F) and hamster sebums showed different properties from human sebum.
33 citations,
June 2007 in “International Journal of Pharmaceutics” The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
29 citations,
May 2007 in “International journal of pharmaceutics” Different compounds move through artificial sebum at different rates, which can help choose the best ones for targeting hair follicles.
141 citations,
November 2005 in “International journal of pharmaceutics” Hair follicles may soon be used more for targeted and systemic drug delivery.
34 citations,
July 2010 in “Expert Opinion on Drug Delivery” The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.
26 citations,
March 2014 in “International journal of pharmaceutics” Researchers created a skin treatment that could effectively deliver medication into hair follicles.
33 citations,
June 2007 in “International Journal of Pharmaceutics” The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
10 citations,
April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
141 citations,
November 2005 in “International journal of pharmaceutics” Hair follicles may soon be used more for targeted and systemic drug delivery.
