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GlossaryConfocal Microscopy

uses laser light to create detailed, three-dimensional images

Confocal Microscopy, also known as Confocal Laser Scanning Microscopy (CLSM), is an advanced imaging technique that uses laser light to scan samples and create high-resolution, three-dimensional images. By focusing on a specific plane within the sample and excluding out-of-focus light, it provides clearer and more detailed images than traditional microscopy, making it particularly useful for studying complex structures like hair follicles and skin tissues in both research and medical diagnostics.

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Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

research Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

21 citations , December 2016 in “European journal of pharmaceutics and biopharmaceutics”

Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.

research Drug delivery to the hair follicle : role of follicular tight junctions as a biological barrier and the potential for targeting clobetasol nanocarriers

January 2015 in “SciDok (Saarland University and State Library)”

Clobetasol nanocarriers can be effectively delivered to hair follicles, with uptake improved by massage and affected by particle type.

research Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles

4 citations , July 2023 in “Pharmaceutics (Basel)”

Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.

Measuring Changes in Chemistry, Composition, and Molecular Structure Within Hair Fibers by Infrared and Raman Spectroscopic Imaging

research Measuring Changes in Chemistry, Composition, and Molecular Structure Within Hair Fibers by Infrared and Raman Spectroscopic Imaging

42 citations , January 2011 in “Journal of Biomedical Optics”

Infrared and Raman imaging can non-destructively analyze hair structure and help diagnose hair conditions.

research Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane

211 citations , June 2012

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

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community Verteporfin and Microneedling

in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.