Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy

August 2016 in “ Nanomedicine ”

Tannaz Ramezanli, Zheng Zhang, Bożena Michniak-Kohn

adapalene synthetic retinoid polymeric nanoparticle ABA triblock copolymer TyroSpheres micellar-like nanocarriers hydrophobic drugs solubility penetration aqueous media sustained release therapeutic efficacy acne treatment retinoid nanoparticles micelles drug delivery skin penetration acne therapy

TLDR The new adapalene formulation using TyroSpheres is more effective and less irritating for acne treatment.

The study focused on developing and characterizing a polymeric nanoparticle-based formulation of adapalene, a synthetic retinoid used for topical acne therapy. The researchers used an ABA triblock copolymer to create TyroSpheres, which are micellar-like nanocarriers capable of encapsulating hydrophobic drugs like adapalene. The formulation aimed to improve the solubility and penetration of adapalene in aqueous media, addressing its low solubility and potential for irritation. The results indicated that the TyroSphere formulation enhanced the solubility and sustained release of adapalene, potentially reducing irritation and improving its therapeutic efficacy for acne treatment.

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