Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy

January 2017 in “ Nanomedicine ”

Tannaz Ramezanli, Zheng Zhang, Bożena Michniak-Kohn

adapalene synthetic retinoid polymeric nanoparticle ABA triblock copolymer TyroSpheres micellar-like nanocarriers hydrophobic drugs solubility penetration aqueous media sustained release therapeutic efficacy acne treatment retinoid nanoparticles micelles drug delivery skin penetration acne therapy

TLDR The new adapalene formulation using TyroSpheres is more effective and less irritating for acne treatment.

The study focused on developing and characterizing a polymeric nanoparticle-based formulation of adapalene, a synthetic retinoid used for topical acne therapy. The researchers used an ABA triblock copolymer to create TyroSpheres, which are micellar-like nanocarriers capable of encapsulating hydrophobic drugs like adapalene. The formulation aimed to improve the solubility and penetration of adapalene in aqueous media, addressing its low solubility and potential for irritation. The results indicated that the TyroSphere formulation enhanced the solubility and sustained release of adapalene, potentially reducing irritation and improving its therapeutic efficacy for acne treatment.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

7 / 7 results

research Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination

38 citations , May 2015 in “Journal of controlled release”

IMSG nanoparticles improve vaccine delivery and immune response through hair follicles.

research Development, Formulation, and Characterization of an Adapalene-Loaded Solid Lipid Microparticle Dispersion for Follicular Penetration

26 citations , May 2014 in “International journal of pharmaceutics”

Researchers created a skin treatment that could effectively deliver medication into hair follicles.

research Polymeric Nanoparticles-Based Topical Delivery Systems for the Treatment of Dermatological Diseases

263 citations , February 2013 in “Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology”

Polymeric nanoparticles show promise for treating skin diseases.

research Investigation of Drug Partition Property in Artificial Sebum

33 citations , January 2008 in “International Journal of Pharmaceutics”

The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations , June 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The new "differential stripping" method effectively measures how much substance gets into hair follicles.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.