Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders

    May 2022 in “ Asian Journal of Pharmaceutical Sciences ”
    Ye Gu, Qiong Bian, Yanjun Zhou … Gao J
    Studysummary This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 68

    1. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    2. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    3. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    4. Minoxidil-Coated Lysozyme-Shelled Microbubbles Combined With Ultrasound for the Enhancement of Hair Follicle Growth: Efficacy In Vitro and In Vivo Frontiers in Pharmacology · 2021
    5. Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability Molecules · 2021
    6. An Updated Review of the Sebaceous Gland and Its Role in Health and Diseases Part 2: Pathophysiological Clinical Disorders of Sebaceous Glands Dermatologic Therapy · 2021
    7. Thiolated and PEGylated Silica Nanoparticle Delivery to Hair Follicles International journal of pharmaceutics · 2020
    8. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    9. Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia AAPS PharmSciTech · 2020
    10. In Vitro Performance of Dutasteride-Nanostructured Lipid Carriers Coated with Lauric Acid-Chitosan Oligomer for Dermal Delivery Pharmaceutics · 2020
    11. Investigation of Transfollicular Caffeine Penetration Using Microdialysis on Ex Vivo Porcine Ear Skin European journal of pharmaceutics and biopharmaceutics · 2020
    12. Hair Follicle Targeting With Curcumin Nanocrystals: Influence of Formulation Properties on Penetration Efficacy Journal of Controlled Release · 2020
    13. Microneedling: A Novel Therapeutic Approach for Androgenetic Alopecia, A Review of Literature Dermatologic Therapy · 2020
    14. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020
    15. Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth AAPS PharmSciTech · 2020
    16. Developing Formulations for Drug Follicular Targeting: Nanoemulsions Loaded with Minoxidil and Clove Oil Journal of drug delivery science and technology · 2020
    17. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    18. Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment Polymers · 2020
    19. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    20. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    21. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    22. Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia Cutaneous and Ocular Toxicology · 2019
    23. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    24. Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia Biomaterials Research · 2019
    25. Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice International Journal of Nanomedicine · 2019
    26. Phospholipid-Polymer Hybrid Nanoparticle-Mediated Transfollicular Delivery of Quercetin: Prospective Implementation for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2019
    27. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    28. A Simple Non-Invasive Approach Toward Efficient Transdermal Drug Delivery Based on Biodegradable Particulate System ACS Applied Materials & Interfaces · 2019
    29. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    30. Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting Pharmaceutical development and technology · 2019
    31. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    32. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    33. Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal European Journal of Pharmaceutical Sciences · 2018
    34. Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach Drug Design Development and Therapy · 2018
    35. Nanoemulsion Vehicles as Carriers for Follicular Delivery of Luteolin ACS Biomaterials Science & Engineering · 2018
    36. Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth Biomaterials · 2018
    37. Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting Pharmaceutics · 2018
    38. Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers Nanoscale · 2017
    39. Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine Journal of Drug Delivery Science and Technology · 2017
    40. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    41. Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability Journal of pharmaceutical sciences · 2017
    42. Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery European Journal of Pharmaceutics and Biopharmaceutics · 2017
    43. Synthesis and Validation of Functional Nanogels as pH-Sensors in the Hair Follicle Macromolecular bioscience · 2017
    44. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia Skin Pharmacology and Physiology · 2017
    45. Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia Artificial Cells Nanomedicine and Biotechnology · 2016
    46. Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy Nanomedicine · 2016
    47. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers Aaps Pharmscitech · 2016
    48. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study Advanced Pharmaceutical Bulletin · 2016
    49. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study PubMed · 2016
    50. Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth Theranostics · 2016
    51. Triggered Release of Model Drug from Gold Nanoparticle-Doped Bovine Serum Albumin Nanocarriers in Hair Follicles Using Infrared A Radiation Acta Biomaterialia · 2015
    52. Depositing Alpha-Mangostin Nanoparticles to Sebaceous Gland Area for Acne Treatment Journal of pharmacological sciences · 2015
    53. Roxithromycin-Loaded Lipid Nanoparticles for Follicular Targeting International Journal of Pharmaceutics · 2015
    54. Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2015
    55. Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells Nanomedicine: Nanotechnology, Biology and Medicine · 2015
    56. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    57. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    58. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    59. Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia Dermatologic Therapy · 2014
    60. Polymeric Nanoparticles-Embedded Organogel for Roxithromycin Delivery to Hair Follicles European Journal of Pharmaceutics and Biopharmaceutics · 2014
    61. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    62. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    63. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012
    64. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    65. Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles Journal of Biomedical Optics · 2009
    66. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    67. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    68. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004