Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

January 2016 in “ Drug Development and Industrial Pharmacy ”

Hamed Hamishehkar, Saeed Ghanbarzadeh, Sasan Sepehran, Yousef Javadzadeh, Zahra Mardhiah Adib, Maryam Kouhsoltani

flutamide solid lipid nanoparticles androgenic alopecia hair follicles

TLDR Flutamide, delivered by solid lipid nanoparticles, could potentially treat hair loss.

The document titled "Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia" from 2015 investigated the potential of flutamide, delivered via solid lipid nanoparticles, as a treatment for androgenic alopecia. The study found that these nanoparticles were successful in delivering flutamide to hair follicles, which could potentially help in treating androgenic alopecia. However, the document did not provide the number of participants in the study, limiting the strength of the conclusions.

View this study on tandfonline.com →

Discuss this study in the Community →

Cited in this study

12 / 12 results

research Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream

34 citations , November 2014 in “European journal of pharmaceutics and biopharmaceutics”

The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.

research Development, Formulation, and Characterization of an Adapalene-Loaded Solid Lipid Microparticle Dispersion for Follicular Penetration

26 citations , May 2014 in “International journal of pharmaceutics”

Researchers created a skin treatment that could effectively deliver medication into hair follicles.

research Influence of Massage and Occlusion on the Ex Vivo Skin Penetration of Rigid Liposomes and Invasomes

39 citations , February 2014 in “European journal of pharmaceutics and biopharmaceutics”

Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.

research Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

58 citations , March 2013 in “Aaps Pharmscitech”

LCN may improve finasteride delivery for hair loss treatment.

research Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane

211 citations , June 2012

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

268 citations , July 2009 in “International Journal of Pharmaceutics”

Niosomes improve minoxidil skin delivery for hair loss treatment.

research Targeted Transfollicular Delivery of Artocarpin Extract from Artocarpus Incisus by Means of Microparticles

24 citations , November 2007 in “European Journal of Pharmaceutics and Biopharmaceutics”

Microparticles containing artocarpin extract could effectively treat hair loss and acne with minimal side effects.

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

127 citations , October 2006 in “International Journal of Pharmaceutics”

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

research New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects

45 citations , March 2005 in “Steroids”

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

research Androgens and Alopecia

165 citations , December 2002 in “Molecular and Cellular Endocrinology”

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

research Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism

32 citations , July 1999 in “Fertility and Sterility”

Finasteride and flutamide both reduce hair growth, but finasteride has fewer side effects.

research Treatment of Hirsutism with the Pure Antiandrogen Flutamide

130 citations , September 1990 in “Journal of the American Academy of Dermatology”

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.