New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice

January 2000 in “ International Journal of Pharmaceutics ”

Amnon Sintov, Sima Serafimovich, Amos Gilhar

finasteride flutamide topical antiandrogenic formulations male-pattern baldness androgenic alopecia SCID mice hair follicles Propecia topical antiandrogens

TLDR Topical treatments can regrow hair on bald scalps.

The study tested topical formulations of finasteride and flutamide on human bald scalp grafts transplanted onto SCID mice to evaluate their effectiveness in treating male-pattern baldness. Both formulations significantly increased the number of hairs per graft, as well as hair length and diameter, compared to a placebo. Flutamide was found to be more effective than finasteride, with 1.22±0.47 hairs/0.5 mm² graft and hair lengths of 5.82±0.50 mm, compared to finasteride's 0.88±0.95 hairs/0.5 mm² graft and 4.50±0.32 mm hair lengths. The study suggested that these topical formulations could effectively reverse male-pattern baldness by re-enlarging hair follicles.

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Research cited in this study

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RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.

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The document discussed various dermatologic research techniques, including the use of animal models such as guinea pigs, mice, and rats to study skin conditions and drug effects. It highlighted the use of scalp grafts on nude mice as a model for human hair growth, which was relevant for hair growth drug screening. The document also covered methods for measuring skin color, testing phototoxicity, and evaluating drug and cosmetic effects on the skin. Additionally, it explored the use of peptide-copper complexes in stimulating hair follicles, with studies conducted on both humans and animals. These techniques provided insights into dermatopharmacology and the pathophysiology of skin conditions.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

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research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

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Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

research The Effect of Topical Cyclosporin on the Immediate Shedding of Human Scalp Hair Grafted onto Nude Mice

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Topical cyclosporin may help delay hair loss.

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New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice

Research cited in this study

research A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Dermatologic Research Techniques

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

research The Effect of Topical Cyclosporin on the Immediate Shedding of Human Scalp Hair Grafted onto Nude Mice

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