New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice

    Amnon Sintov, Sima Serafimovich, Amos Gilhar
    Studysummary In a study using human scalp skin grafts on SCID mice, topical flutamide and finasteride significantly improved hair growth in male-pattern baldness compared to placebo, with flutamide showing superior results to finasteride.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 10

    1. A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice British Journal of Dermatology · 1997
    2. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    3. Dermatologic Research Techniques CRC Press eBooks · 1996
    4. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995
    5. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    6. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    7. Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque The Journal of Clinical Endocrinology and Metabolism · 1992
    8. Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque The Journal of Clinical Endocrinology and Metabolism · 1992
    9. Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness Journal of Investigative Dermatology · 1989
    10. The Effect of Topical Cyclosporin on the Immediate Shedding of Human Scalp Hair Grafted onto Nude Mice British Journal of Dermatology · 1988

    Related research 9

    1. Safety and Efficacy of Trimax-360 Serum in Healthy Adult Subjects with Mild to Moderate Alopecia of the Scalp Journal of Cosmetic Dermatology · 2022
    2. Evaluation of the Effect of Topically Applied Methylsulfonylmethane and Their Combination with Minoxidil Solution for Improvement of Hair Growth in Male Mice Wiadomości lekarskie (Warsaw Poland) · 2022
    3. Effects of Mixed Medicinal Herbal Extract on Hair Growth in Mice with Alopecia 2014
    4. Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women Journal der Deutschen Dermatologischen Gesellschaft · 2007
    5. A Quantitative Hair Growth Assessment in Androgenetic Alopecia After Application of Two Cosmetic Lotions Versus 2% Topical Minoxidil Journal of The American Academy of Dermatology · 2005
    6. KF19418, A New Compound for Hair Growth Promotion in Vitro and in Vivo Mouse Models Journal of Dermatological Science · 2001
    7. Lack of Effect of Topical Minoxidil on Scalp Sebum Production Journal of Dermatological Treatment · 1991
    8. Comparable Efficacy of 2% Minoxidil Gel and Solution Formulations in the Treatment of Male Pattern Alopecia Journal of the American Academy of Dermatology · 1988
    9. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987