Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream

    October 2014 in “ European journal of pharmaceutics and biopharmaceutics ”
    Andreas Lauterbach, Christel C. Müller‐Goymann
    Studysummary This study found that adapalene-loaded solid lipid microparticles may enhance targeted drug delivery into sebum due to their similarity to sebum components, although both this formulation and a standard cream showed equivalent follicular penetration.
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    Research cited in this study 11

    1. Development, Formulation, and Characterization of an Adapalene-Loaded Solid Lipid Microparticle Dispersion for Follicular Penetration International journal of pharmaceutics · 2014
    2. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    3. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    4. Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing The AAPS Journal · 2012
    5. Non-Invasive Analysis of Penetration and Storage of Isoconazole Nitrate in the Stratum Corneum and Hair Follicles European Journal of Pharmaceutics and Biopharmaceutics · 2012
    6. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    7. Comparison of Artificial Sebum with Human and Hamster Sebum Samples International journal of pharmaceutics · 2008
    8. Investigation of Drug Partition Property in Artificial Sebum International Journal of Pharmaceutics · 2007
    9. Diffusion Properties of Model Compounds in Artificial Sebum International journal of pharmaceutics · 2007
    10. Comparison of Stratum Corneum Penetration and Localization of a Lipophilic Model Drug Applied in an O/W Microemulsion and an Amphiphilic Cream European journal of pharmaceutics and biopharmaceutics · 2007
    11. Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin European journal of pharmaceutical sciences · 2003