TLDR Isoconazole nitrate stays effective in skin and hair follicles for up to two weeks after use.
The study investigated the penetration and storage of Isoconazole nitrate, an anti-fungal drug, in the stratum corneum and hair follicles using a differential tape stripping method over a 14-day application period and a 21-day follow-up. Conducted on 10 healthy volunteers, the study found that Isoconazole nitrate remained in concentrations above the minimal inhibition level in both the stratum corneum and hair follicles one week after application ended, and in some cases, even after 14 days. This indicated that hair follicles could serve as a long-term reservoir for the drug, providing a prolonged therapeutic effect. The study also confirmed that the differential stripping method was effective for analyzing the penetration and storage of topically applied substances without impairing the skin's barrier function.
162 citations,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The new "differential stripping" method effectively measures how much substance gets into hair follicles.
405 citations,
January 2004 in “Journal of Investigative Dermatology” Hair follicle size and distribution vary significantly across different body sites.
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34 citations,
October 2014 in “European journal of pharmaceutics and biopharmaceutics” The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.
35 citations,
October 2015 in “International Journal of Pharmaceutics” Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.
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2 citations,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
61 citations,
May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
October 2001 in “WORLD SCIENTIFIC eBooks” Many substances, including chemicals and metals, can cause skin reactions; careful handling and identification of allergens are crucial to prevent dermatitis.
