Roxithromycin-Loaded Lipid Nanoparticles for Follicular Targeting

October 2015 in “ International Journal of Pharmaceutics ”

Hanna Wosicka-Frąckowiak, Krzysztof Cal, Justyna Stefanowska, Eliza Główka, Magdalena Nowacka, Wiktoria Struck-Lewicka, Biljana Govedarica, Monika Pasikowska, Renata Dębowska, Teofil Jesionowski, Stanko Srčič, Michał J. Markuszewski

roxithromycin solid lipid nanoparticles SLN hair follicles encapsulation efficiency skin irritation hair bulb in vivo studies follicular biopsies skin penetration ROX

Studysummary Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation. Our plain-language summary of this paper — not a Tressless recommendation.

The document presents a study on the development and evaluation of roxithromycin-loaded solid lipid nanoparticles (SLN) for targeted delivery to hair follicles. The study showed that the SLN had a high encapsulation efficiency of 82.1% and could release approximately 21% of roxithromycin (ROX) after 24 hours. The SLN, with a size below 200 nm, did not cause skin irritation and demonstrated efficient delivery to the hair bulb. In vivo studies quantified ROX in follicular biopsies, indicating that the SLN could effectively deliver ROX to hair follicles. However, the small sample size (n=3) for measuring skin penetration limits the strength of the conclusions. Further research with a larger group of volunteers is needed to confirm these findings.

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