Fabrication and Evaluation of Vitamin-Doped ZnO/AgNPs Nanocomposite Based Wheat Gluten Films: Promising Findings for Burn Wound Treatment

The study evaluated wheat gluten (WG) films doped with zinc oxide nanoparticles (ZnO NPs), silver nanoparticles (Ag NPs), and vitamins A and E for burn wound treatment. The films showed antioxidant and antibacterial properties, controlled swelling, and sustained release of vitamins and nanoparticles. In vivo experiments on mice demonstrated that the films promoted wound healing processes such as wound contraction, re-epithelialization, collagen deposition, and hair follicle development within 14 days. The WG/P/Zn/E and WG/A/Ag/E films were particularly effective, leading to complete wound closure by the 14th day. The study concluded that these nanocomposite films are promising for burn wound treatment due to their physiochemical and biological properties, and their ability to accelerate the healing process while being biocompatible and biodegradable.