Recent Insights Into the Potential and Challenges of Sericin as a Drug Delivery Platform for Multiple Biomedical Applications
May 2025
in “
Pharmaceutics
”
Studysummary In this review, researchers evaluated sericin-based drug delivery systems for antimicrobial, anticancer, and neurodegenerative treatments, highlighting its potential benefits and challenges related to molecular variability and formulation stability, suggesting future focus on optimizing extraction and integration with advanced biomedical technologies.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Sericin, a glycoprotein from silk cocoons, is highlighted as a promising biomaterial for drug delivery due to its biocompatibility, biodegradability, and ability to interact with various drugs. Recent advancements include sericin-based nanoparticles, hydrogels, and microneedles for antimicrobial, anticancer, and neurodegenerative applications. These systems enhance drug encapsulation, targeted release, and therapeutic efficacy, while reducing side effects. Despite its potential, challenges such as molecular variability, formulation stability, and regulatory issues persist. Future research should focus on optimizing sericin extraction and integrating it with advanced technologies to maximize its therapeutic potential.
