Injectable Biomimetic Gels for Biomedical Applications

July 2024 in “ Biomimetics ”

Hossein Omidian, Renae L. Wilson, Sumana Dey Chowdhury

Studysummary This manuscript explores the development and future potential of injectable biomimetic gels in biomedical applications, highlighting their promise in wound healing and tissue regeneration, while also acknowledging challenges like mechanical durability and scalable production still persist.

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Injectable biomimetic gels are advancing biomedical applications by mimicking the extracellular matrix to support tissue regeneration, wound healing, and drug delivery. These hydrogels, made from materials like gelatin, chitosan, and hyaluronic acid, exhibit properties such as self-healing, mechanical flexibility, and biocompatibility. They have shown promise in promoting vascularization, bone regeneration, and cartilage formation, with specific examples including ECM-mimetic hydrogels and alginate bioconjugates. Despite their potential, challenges remain in enhancing mechanical resilience, degradation control, and targeted delivery. Future research aims to optimize these properties and integrate technologies like 3D bioprinting to fully realize their potential in regenerative medicine.

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