Predictive Design Framework for Electrospun Pectin Nanofibers in Biomedical Applications

This review discusses the potential of pectin, a plant-derived polysaccharide, as a platform for creating bioinstructive nanofibrous scaffolds in biomedical applications. Pectin's unique properties, such as mucoadhesiveness and immunomodulatory potential, make it a promising alternative to other natural polymers. The review introduces a predictive framework for designing electrospun pectin nanofibers, focusing on molecular strategies (covalent, physical, and compositional) that influence fiber formation and biological performance. It also addresses challenges like material variability and regulatory issues. The goal is to advance pectin nanofibers from prototypes to clinically viable solutions for regenerative medicine and therapeutic delivery.