Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

The study developed chitosan-modified fucoidan (FD)/ultra-high molecular weight polyethylene oxide (UHMWPEO) nanofibers using green electrospinning to explore their interaction with endothelial cells. The research found that the electrospinnability and thermo-stability of the nanofibers were significantly enhanced by incorporating UHMWPEO, with no phase separation observed in the solutions. In vitro experiments demonstrated that these nanofibers improved endothelial cell adhesion while inhibiting monocyte attachment, indicating their potential as bio-scaffolds for tissue-engineered blood vessels.