Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

The study investigated the development of fucoidan-based electrospun nanofibers combined with ultra-high molecular weight polyethylene oxide (UHMWPEO) for vascular tissue engineering. By addressing fucoidan's low viscoelasticity and solubility, the researchers successfully electrospun nanofibers, which were then modified with chitosan to improve interaction with human umbilical vein endothelial cells (HUVECs). The optimal weight ratio of fucoidan to PEO was found to be 90:10, resulting in defect-free nanofibers with enhanced spinnability and thermal stability. These nanofibers promoted cellular attachment and reduced inflammatory responses by inhibiting monocyte adhesion, highlighting their potential in vascular tissue engineering. The use of water as a solvent in the electrospinning process was noted for its environmental benefits.