Injectable Gelatin Microspheres Loaded with Platelet Rich Plasma Improve Wound Healing by Regulating Early Inflammation

    Shaolong Zhou, Li Li, Chen Chen, Yi Chen, Linhua Zhou, Fiona H. Zhou, Jianghui Dong, Liping Wang
    TLDR Injectable gelatin microspheres with platelet-rich plasma speed up wound healing.
    The study investigated the use of gelatin microspheres (GMs) loaded with platelet-rich plasma (PRP) to enhance wound healing in a rat model. The combination of GMs and PRP (GM+PRP) was found to significantly accelerate the wound healing process compared to PRP or GMs alone. GM+PRP improved the healing rate, dermal structure, and angiogenesis by increasing the expression of angiogenic factors and prolonging cytokine release. The study concluded that GMs serve as an effective injectable carrier that enhances the therapeutic effects of PRP by promoting inflammatory and angiogenic responses, leading to improved wound healing outcomes.
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