Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

November 2020 in “ International Journal of Molecular Sciences ”

Antonio Martínez-López, Trinidad Montero-Vilchez, Álvaro Sierra-Sánchez, Alejandro Molina-Leyva, Salvador Arias-Santiago

alopecia areata androgenic alopecia gene therapy cell therapy tissue engineering human mesenchymal stem cells hMSCs mesenchymal stem cells MSCs adipose cells regenerative medicine hair regrowth hair follicles stem cells fat cells

TLDR Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

The review "Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia" discusses the potential of advanced therapies, such as gene, cell, and tissue engineering therapies, in treating alopecia areata and androgenic alopecia. The document highlights the potential of human mesenchymal stem cells (hMSCs) in regenerative medicine, including their application in dermatology for repairing and regenerating skin abnormalities. Various studies are discussed, including those involving the use of mesenchymal stem cells (MSCs), adipose cells, and gene therapy. Results show promising hair regrowth and improvement in alopecia conditions, with one study even regenerating 225 hair follicles from one hair follicle donor tissue. However, the authors conclude that while these therapies show promise in preclinical studies, more clinical studies are needed to verify their safety and effectiveness for diverse forms of non-scarring alopecia.

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