TLDR Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.
The study investigated the Th1/Th2 peripheral blood balance and CD200 expression in 50 patients with active severe alopecia areata (SAA), 50 with stable SAA, and 50 healthy controls. It found that active SAA patients had significantly lower CD200 expression on CD3+ T lymphocytes and CD19+ B lymphocytes, as well as lower CD200 mRNA levels. Additionally, these patients exhibited higher levels of IFN-γ and lower levels of IL-10, indicating a Th1/Th2 imbalance. The study concluded that decreased CD200 expression and Th1/Th2 imbalance might be associated with the pathogenesis of SAA, suggesting potential targets for therapeutic intervention.
550 citations,
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