Th1/Th2 Peripheral Blood Balance and CD200 Expression in Patients with Active Severe Alopecia Areata
April 2017
in “
Experimental and Therapeutic Medicine
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that patients with active severe alopecia areata exhibited decreased CD200 expression on T and B lymphocytes, which may be linked to an imbalance in Th1/Th2 immune equilibrium. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the Th1/Th2 peripheral blood balance and CD200 expression in 50 patients with active severe alopecia areata (SAA), 50 with stable SAA, and 50 healthy controls. It found that active SAA patients had significantly lower CD200 expression on CD3+ T lymphocytes and CD19+ B lymphocytes, as well as lower CD200 mRNA levels. Additionally, these patients exhibited higher levels of IFN-γ and lower levels of IL-10, indicating a Th1/Th2 imbalance. The study concluded that decreased CD200 expression and Th1/Th2 imbalance might be associated with the pathogenesis of SAA, suggesting potential targets for therapeutic intervention.
