Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

October 2011 in “ British Journal of Dermatology ”

Hamid Reza Goodarzi, Ali Abbasi, Mojtaba Saffari, Maryam Fazelzadeh Haghighi, Kaoru Tabei, Mohammad Reza Noori Daloii

microRNAs miR-221 miR-125b miR-106a miR-410 dermal papilla male pattern baldness gene therapy MPB hair loss

TLDR Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.

The study investigated the role of microRNAs in male pattern baldness by analyzing their expression in the dermal papillae of eight individuals with the condition. The researchers found that four microRNAs (miR-221, miR-125b, miR-106a, and miR-410) were significantly upregulated in balding papilla cells compared to nonbalding cells. These findings suggest that these microRNAs may contribute to the development of male pattern baldness and could be targets for new gene therapy treatments. Although one microRNA (miR-340) was downregulated, the change was not statistically significant. The research indicates a need for further high-throughput studies to better understand the roles of microRNAs in this condition.

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