Histopathological and Topical Immunological Changes in Alopecia

    September 1998 in “ Journal of the European Academy of Dermatology and Venereology ”
    А. В. Самцов
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    TLDR Autoimmune and inflammatory processes are involved in both scarring and non-scarring types of hair loss.
    The document presents a study aimed at understanding the pathogenesis of scarring and non-scarring alopeciae. A total of 31 patients (16 women and 15 men) suffering from these conditions were investigated through histological examination of scalp skin biopsy specimens and immunophenotyping of cell subpopulations. The study found evidence of autoimmune and inflammatory processes in both scarring and non-scarring alopeciae, indicated by changes such as lymphocyte exocytosis into the epidermis, vacuolization of spinous cells, edema of the papillary dermis collagen, hyalinosis of the deep dermis and upper subcutis, and a high quantity of T8 cells and Langerhans' cells in the epidermis. Additionally, more than 50% of follicles were in the catagen stage, and there were traces of monocytes in the hair follicles. These findings suggest that autoimmune and inflammation are involved in the pathogenesis of these types of alopecia.
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