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    Did you mean Papillary Dermis?
    GlossaryPapillary Dermis

    uppermost dermal layer with blood vessels and nerve endings

    The papillary dermis is the uppermost layer of the dermis, which is the thick layer of skin beneath the outer epidermis. It contains thin collagen fibers, small blood vessels, and nerve endings, playing a crucial role in supplying nutrients to the epidermis and regulating temperature. This layer also contributes to the skin's tactile properties and helps in wound healing.

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      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn Exosomes

      Microscopic delivery system that sends growth-promoting signals to hair follicles

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      bioflavonoid found in plants with antioxidant and hair stimulating properties

      learn Redensyl

      commercial product with a blend of mostly natural ingredients for hair regrowth

    Research

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      Skin Connective Tissue and Aging

      research Skin Connective Tissue and Aging

      77 citations, July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”
      Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.
      Antiglycants

      research Antiglycants

      January 2017 in “Clinical approaches and procedures in cosmetic dermatology”
      Anti-glycation treatments might slow skin aging, but more research is needed.
      Structure and Function of the Skin

      research Structure and Function of the Skin

      6 citations, January 2009 in “Elsevier eBooks”
      The skin has multiple layers and cells, serves as a protective barrier, helps regulate temperature, enables sensation, affects appearance, and is involved in vitamin D synthesis.

    Community Join

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      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Vitamin C and hair growth PH levels

      in Product  34 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.