Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models

    October 2018 in “ Experimental Dermatology ”
    Jung Eun Kim, Jee Hye Oh, Young Sup Woo … Hoon Kang
    Studysummary This study suggests that mesenchymal stem cell therapy may improve cell viability and regulate key signaling pathways in vitro for treating alopecia areata.
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    Research cited in this study 9

    1. Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells Lasers in Surgery and Medicine · 2017
    2. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    3. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    4. Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway Experimental Dermatology · 2015
    5. Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia Seminars in cutaneous medicine and surgery · 2015
    6. Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy BMC medicine · 2015
    7. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    8. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    9. TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis Journal of Cellular and Molecular Medicine · 2009

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    2. MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway Journal of Cell Biology · 2014
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    4. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010