Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia

    Thomas W. Chu, Leopoldo Duailibe Nogueira Santos, Kevin J. McElwee
    TLDR Hair loss can be caused by various factors, and treatments focus on restoring normal hair growth.
    The document reviewed the basic biology of the hair follicle and the mechanisms behind various hair disorders, both nonscarring and scarring alopecia. It highlighted that hair disorders involve changes in hair fiber caliber, density, and the duration of hair growth phases (anagen and telogen). These disorders could be triggered by factors such as inflammation, genetics, environment, or hormones. Treatments aimed to normalize the hair growth cycle, modulate hair follicle size, and potentially regenerate hair follicles to maintain hair density. The review used selected examples to illustrate these points.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Do hair follicles dies or are dormant ?

      in Finasteride/Dutasteride  92 upvotes 10 months ago
      Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

      community Am I missing something with pp405?

      in Research/Science  37 upvotes 9 months ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

      community How is there still no consensus on Topical Dutasteride in 2024?

      in Finasteride/Dutasteride  147 upvotes 1 year ago
      The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

      community My scalp punch biopsy results🤔?

      in Female  8 upvotes 2 years ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

    Related Research

    7 / 7 results