Biology of the Hair Follicle and Mechanisms of Nonscarring and Scarring Alopecia

    June 2015 in “ Seminars in cutaneous medicine and surgery ”
    Thomas W. Chu, Leopoldo Duailibe Nogueira Santos, Kevin J. McElwee
    TLDR Hair loss can be caused by various factors, and treatments focus on restoring normal hair growth.
    The document reviewed the basic biology of the hair follicle and the mechanisms behind various hair disorders, both nonscarring and scarring alopecia. It highlighted that hair disorders involve changes in hair fiber caliber, density, and the duration of hair growth phases (anagen and telogen). These disorders could be triggered by factors such as inflammation, genetics, environment, or hormones. Treatments aimed to normalize the hair growth cycle, modulate hair follicle size, and potentially regenerate hair follicles to maintain hair density. The review used selected examples to illustrate these points.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Finasteride/Dutasteride  92 upvotes 11 months ago
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      community Am I missing something with pp405?

      in Research/Science  35 upvotes 9 months ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

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      in Finasteride/Dutasteride  147 upvotes 1 year ago
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      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 1 week ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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