Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

    March 2024 in “ International Journal of Molecular Sciences ”
    Charlotte E. Berry, Camille Brenac, Caroline E. Gonzalez, Carter B. Kendig, Thalia Le, Nicholas An, Michelle Griffin
    TLDR Natural compounds and biomimetic engineering can improve wound healing by enhancing fibroblast activity.
    The review highlights the potential of natural compounds and biomimetic engineering in enhancing wound healing by influencing fibroblast behavior. Natural compounds, particularly botanicals and plant-derived products, have been historically significant in wound healing due to their efficacy and minimal side effects, with 70-80% of the global population relying on them. Research on 23 medicinal seaweed species identified Sargassum illicifolium and Haliimeda opuntin as effective in promoting fibroblast proliferation. Biomimetic engineering, including electrospun nanofibers, mimics the skin's extracellular matrix to regulate fibroblast activity. Advanced drug delivery systems, such as nano-drug delivery systems, improve drug bioavailability and create a moist environment beneficial for healing. Despite these advancements, challenges remain in translating findings to clinical settings, including validation in large animal models and production logistics. Integrating ancient remedies with modern approaches shows promise for effective, scar-free wound healing.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 42 results

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

      in Research/Science  137 upvotes 8 months ago
      Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

      community Day 155 of 5mg oral minoxidil + 0,5mg oral dutasteride daily

      in Progress Pictures  103 upvotes 1 month ago
      A user shared progress on hair regrowth using 5mg oral minoxidil and 0.5mg oral dutasteride daily, noting small hair growth and no significant side effects except bushier eyebrows. The conversation includes encouragement, personal experiences with hair loss treatments, and discussions on the effectiveness of microneedling.

      community One year on finasteride has reversed some aging

      in Chat  198 upvotes 5 months ago
      Finasteride and minoxidil use resulted in a more youthful appearance and improved skin. There is debate about their effects on collagen and skin aging, with no solid evidence supporting significant changes due to finasteride.

    Similar Research

    5 / 1000+ results