Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration

The document "Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration" discusses the limitations of current skin regeneration treatments and the potential of tissue engineering materials that mimic the extracellular matrix (ECM). The focus is on maximizing cellular functions related to tissue regeneration. The skin's structure and wound healing process are explained, with emphasis on the use of 3D porous materials and nanofibers in wound dressings. Four main tissue engineering approaches are highlighted: Electrospun sheets, sponges, hydrogels, and composite materials. The document also discusses the incorporation of drug delivery systems, growth factors, and cells, as well as mechanobiological approaches. Despite the diversity of current dressing approaches, the document concludes that there is a need for materials with enhanced functionality to address delays in infection and tissue regeneration, especially in chronic wounds. Future research should focus on the recognition mechanism of mechanical stimuli based on factors such as cell-cell interactions in material structures that mimic the environment of living organisms.