Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Microneedles (MNs) are a promising transdermal drug delivery system for treating skin diseases, including acne, alopecia, and scars, by enhancing drug absorption and targeting specific conditions. They improve treatment efficacy in acne by using zinc porphyrin-based composites to kill bacteria and stimulate hair growth in alopecia with compounds like quercetin. For scars, MNs combined with exosomes effectively remodel the skin. Despite their potential, challenges such as limited dosing capacity and material safety need addressing. Innovations like dissolving MNs with minoxidil for hair regrowth and integrating MNs with photothermal therapy highlight their versatility in improving skin disease management.