Combining Rapid Degrading Microneedles With Slow-Released Drug Delivery System for the Treatment of Alopecia Areata

    June 2023 in “ Chemical engineering journal ”
    Tikai Zhang, Baode Sun, Wang Ding … Jie Ren
    Studysummary In this laboratory study, a novel minoxidil-loaded microneedle patch demonstrated potential for treating alopecia areata by promoting slow drug release and reducing application frequency, while exhibiting antibacterial properties to prevent infection during use.
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    Research cited in this study 19

    1. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    2. Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice Pharmaceutics · 2021
    3. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    4. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    5. Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial Dermatologic Therapy · 2020
    6. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    7. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    8. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    9. Development of Finasteride Polymer Microspheres for Systemic Application in Androgenic Alopecia International Journal of Molecular Medicine · 2019
    10. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    11. A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia Skin appendage disorders · 2018
    12. Minoxidil in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2018
    13. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    14. Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth Biomaterials · 2018
    15. Experimental and Early Investigational Drugs for Androgenetic Alopecia Expert Opinion on Investigational Drugs · 2017
    16. Androgenetic Alopecia: A Review Endocrine · 2017
    17. Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation Archives of Dermatological Research · 2017
    18. Guidelines on the Use of Finasteride in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2016
    19. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996

    Related research 3

    1. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    2. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    3. Effectivity of Minoxidil as a Treatment for Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2013