Development of Finasteride Polymer Microspheres for Systemic Application in Androgenic Alopecia

    March 2019 in “ International Journal of Molecular Medicine ”
    Ju Han Kim, Jungtae Na, Dong-Ho Bak, Byung Seok Lee, Esther J. Lee, Mi Ran Choi, Choong-Min Ryu, Sangno Lee, Seong Ki Mun, Byung Joo Park, Beom Joon Kim, H. Lee
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    TLDR Finasteride microspheres help reduce hair loss for up to eight weeks with fewer side effects.
    The study aimed to develop a systemic delivery system for finasteride, a drug used to treat androgenic alopecia (AGA), with fewer adverse effects. The researchers developed finasteride-loaded microspheres and tested their efficacy in inhibiting 5a-reductase, a key enzyme in AGA. The study found that a single dose of finasteride-loaded microspheres effectively alleviated hair loss for over four weeks, and its effectiveness for up to eight weeks was confirmed. The study suggests that the effect of finasteride-loaded microspheres does not appear immediately following administration, but rather there is a delayed onset of drug efficacy following the initial dosing. The study concludes that the evaluation of a novel dosage form demonstrated the possibility of an effective novel dose and administration route for finasteride.
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      Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

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      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

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      in Finasteride/Dutasteride  83 upvotes 3 years ago
      The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

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