Optimization of Microstructured Biodegradable Finasteride Formulation for Depot Parenteral Application

    February 2016 in “ Journal of Microencapsulation ”
    Osama M. Ahmed, Amal K. Hussein, Fatma M. Mady
    Image of study
    TLDR Improved finasteride formula allows slow, sustained release and better absorption for patients.
    The study aimed to optimize a microstructured biodegradable finasteride formulation for depot parenteral application. The optimized formula showed a sustained release pattern with minimal initial burst release when injected into rabbits. The pharmacokinetic study revealed that the injected microspheres showed flip-flop pharmacokinetics with slow and sustained release from the polymeric blend and an increase in AUC and Tmax compared with the oral FIN suspension. The optimized formulation provides complete absorption from the injection site, with the intended slow-release pharmacokinetic profile that could possibly improve patient compliance.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community 25M - 4 month progress on min + fin

      in Progress Pictures  257 upvotes 2 months ago
      A 25-year-old shared his 4-month progress using oral minoxidil, oral finasteride, a 1mm dermastamp, Nizoral, and upgraded shampoo and conditioner. He feels he sees some regrowth, though some commenters attribute the change to a different hairstyle.

      community DHT blocking ingredients

      in Treatment  6 upvotes 3 years ago
      The conversation discusses DHT blocking treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and organic flaxseed oil containing omega-3 fatty acids. It highlights skepticism about alternative treatments and emphasizes the proven effectiveness of Finasteride and Dutasteride.

      community Why are more people not using RU58841

      in Product  14 upvotes 7 months ago
      People are not using RU58841 for hair loss because it's not FDA approved, lacks long-term safety data, and is difficult to obtain and verify. They prefer FDA-approved treatments like minoxidil, finasteride, ketoconazole shampoo, and microneedling.

      community For those that have used anti androgens what is your experience?

      in Research/Science  18 upvotes 7 months ago
      People discussed their experiences with anti-androgens for hair loss, mentioning side effects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.

    Similar Research

    5 / 1000+ results