Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

    March 2021 in “ International Journal of Pharmaceutics ”
    Dong-Hyun Kang, Choong-Min Ryu, Ju Han Kim, Go-Wun Choi, Se-Yeon Kim, Chan Hee Chon, Hea-Young Cho
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    TLDR Optimal long-acting finasteride injection dose found: 16.8 mg, effective for one month.
    This document discusses a study that developed a long-acting injectable form of finasteride for treating hair loss and created a model to predict the optimal dosage using pharmacokinetic-pharmacodynamic modeling. The study tested different ratios and conditions to create finasteride-loaded microspheres and found that PLGA 7525A was effective in maintaining a suitable drug concentration level for one month. The optimal dose was found to be 16.8 mg based on predicted PK-PD profiles. The study also conducted repeat dose toxicity tests on male beagle dogs and found no serious toxicological signs.
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