Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

March 2021 in “ International Journal of Pharmaceutics ”

Dong-Hyun Kang, Choong-Min Ryu, Ju Han Kim, Go-Wun Choi, Se-Yeon Kim, Chan Hee Chon, Hea-Young Cho

finasteride long-acting injectable hair loss pharmacokinetic-pharmacodynamic modeling PLGA 7525A microspheres repeat dose toxicity Propecia

TLDR Optimal long-acting finasteride injection dose found: 16.8 mg, effective for one month.

This document discusses a study that developed a long-acting injectable form of finasteride for treating hair loss and created a model to predict the optimal dosage using pharmacokinetic-pharmacodynamic modeling. The study tested different ratios and conditions to create finasteride-loaded microspheres and found that PLGA 7525A was effective in maintaining a suitable drug concentration level for one month. The optimal dose was found to be 16.8 mg based on predicted PK-PD profiles. The study also conducted repeat dose toxicity tests on male beagle dogs and found no serious toxicological signs.

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Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

Research cited in this study

research Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

research Optimization of Microstructured Biodegradable Finasteride Formulation for Depot Parenteral Application

research Assessment of the Usefulness of Dihydrotestosterone in the Diagnostics of Patients with Androgenetic Alopecia

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research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

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