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Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

research Pharmacokinetic-pharmacodynamic modeling approach for dose prediction of the optimal long-acting injectable formulation of finasteride

6 citations , March 2021 in “International Journal of Pharmaceutics”

This study reported that a subcutaneous injection formulation using PLGA microspheres to release finasteride stably achieved sustained monthly drug delivery without burst release in beagle dogs, with a dose of 16.8 mg identified as optimal for potential first-in-human trials.

Non-Clinical Safety Evaluation and Risk Assessment of Aleglitazar, a Dual PPAR α/γ Agonist, and Its Major Human Metabolite

research Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite

3 citations , March 2017 in “Regulatory toxicology and pharmacology”

In this study, aleglitazar and its metabolite M6 were evaluated for safety in non-clinical settings, revealing organ-targeting effects common to PPAR agonists but no significant tumor increase in rat carcinogenicity studies, supporting progression to Phase 3 clinical trials.

research Problems Associated with the Recognition and Confirmation of Low-Dose Endocrine Toxicities

7 citations , October 2003 in “Nonlinearity in Biology Toxicology Medicine”

This review discusses attempts to confirm low-dose effects in rodent endocrine studies and reports no findings; variability in control groups hinders demonstrating weak effects.

research A Case Report on Iatrogenic Methotrexate Toxicity

1 citations , July 2024 in “Cureus”

In this case study, researchers reported on a 54-year-old woman who developed methotrexate toxicity after mistakenly taking high doses over five days, which led to mucocutaneous lesions and pancytopenia, highlighting the importance of early recognition and treatment of such toxicities.

research Case Series Of Selenium Toxicity From A Nutritional Supplement

78 citations , December 2011 in “Clinical toxicology”

This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.

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community Low Dose Dutasteride Stops Hair Loss: 2-3x a Week Use.

187 upvotes 10 months ago

Low-dose Dutasteride, used 2-3 times a week, is as effective as daily Finasteride for hair loss with fewer side effects. Users report increased libido and better results with Dutasteride compared to Finasteride.

community We need more people trying 2.5 mg dutasteride

in Finasteride/Dutasteride 7 upvotes 1 year ago

Increasing the dutasteride dose to 2.5 mg may significantly reduce DHT and promote hair regrowth, with similar side effects to lower doses. Some users combine dutasteride with minoxidil and finasteride for better results, but there are concerns about long-term effectiveness and availability.

community A Nuanced Look at Microdosing Topical Finasteride

86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Extra bonus of taking oral minoxidil 10 mg split morning niggt

in Minoxidil 61 upvotes 4 months ago

The user has been using oral minoxidil at 10 mg daily, split between morning and night, alongside finasteride for 7 years, and reports new hair growth at the temples. Many users express concern over the high minoxidil dosage, citing potential health risks, while others question the effectiveness and necessity of such a dose.

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