A Microfluidic Application for Mass Production of Drug-Loaded Polymeric Microspheres for a Long-Acting Injectable With IVL-DrugFluidic, a Novel Microfluidic Microsphere Manufacturing Platform Technology

April 2023 in “ OpenNano ”

Chan Hee Chon, Ju Hee Kim, Hyunseung On, Jiwoong Choi, Sanghun Lee, Euidon Han

finasteride polymeric microspheres long-acting injectables IVL-DrugFluidic® microfluidic platform encapsulation efficiency plasma levels Propecia LAIs

TLDR IVL-DrugFluidic® can mass-produce high-quality, long-acting injectable drug microspheres, improving patient compliance and reducing side effects.

The study introduces IVL-DrugFluidic®, a novel microfluidic platform for mass-producing finasteride-loaded polymeric microspheres for long-acting injectables (LAIs). This technology optimizes microchannel flow and solvent removal, achieving uniform, defect-free microspheres with nearly 100% encapsulation efficiency. Clinical trials with healthy adult volunteers confirmed stable, month-long drug release without initial burst, demonstrating consistent finasteride plasma levels and dose-proportional increases in exposure. The platform shows significant potential for scalable, high-quality LAI production, enhancing patient compliance and reducing side effects.

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research A Microfluidic Application for Mass Production of Drug-Loaded Polymeric Microspheres for a Long-Acting Injectable With IVL-DrugFluidic, a Novel Microfluidic Microsphere Manufacturing Platform Technology

April 2023 in “OpenNano”

IVL-DrugFluidic® can mass-produce high-quality, long-acting injectable drug microspheres, improving patient compliance and reducing side effects.

A Microfluidic Application for Mass Production of Drug-Loaded Polymeric Microspheres for a Long-Acting Injectable With IVL-DrugFluidic, a Novel Microfluidic Microsphere Manufacturing Platform Technology

Research cited in this study

research Three Months Extended-Release Microspheres Prepared by Multi-Microchannel Microfluidics in Beagle Dog Models

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research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

research Assessment of the Usefulness of Dihydrotestosterone in the Diagnostics of Patients with Androgenetic Alopecia

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