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Glossary Sustained Release

drug delivery system releasing medication slowly over time

Sustained Release (SR), also known as Extended Release (ER) or Controlled Release (CR), refers to a drug delivery system designed to release a medication slowly over time. This allows for a more consistent therapeutic effect, reduces the frequency of dosing, and can improve patient compliance by maintaining steadier drug levels in the bloodstream.

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research Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth

46 citations , January 2020 in “Theranostics”

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

research Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

23 citations , July 2021 in “International Journal of Pharmaceutics”

This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.

research Use of a Sustained Release Preparation of Clotrimazole to Treat Dermatophytosis in a Siamang (Hylobates syndactylus)

10 citations , March 2008 in “Journal of Zoo and Wildlife Medicine”

This case study describes successful treatment of a siamang's persistent Microsporum canis infection using a sustained-release clotrimazole varnish, leading to lesion resolution after two years of clinical signs.

research Sustained release of inhibitor from bionic scaffolds for wound healing and functional regeneration

8 citations , January 2020 in “Biomaterials Science”

In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

research FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

3 citations , December 2016 in “Universal journal of pharmaceutical research”

This study concluded that Finasteride can be effectively delivered in matrix tablets using different polymer ratios for sustained release.

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community Breezula Phase III 12-Month Data Released by Cosmo Pharma

42 upvotes 5 months ago

Clascoterone 5% topical solution is effective and safe for long-term use in treating male pattern hair loss. Cosmo Pharma aims for EU and US approval, with a potential US release in late 2027 or early 2028.

community People are hyped about PP405 but what about Veradermics phase 2!

in Research/Science 39 upvotes 11 months ago

Veradermics' phase 2 trial of slow-release oral minoxidil shows promising hair regrowth with minimized side effects, gaining significant attention and funding. PP405 is also noted for its potential as a side-effect-free alternative.

community Genuine question about VDPHL01's long term safety that I haven't seen discussed here

in Research/Science 28 upvotes 4 months ago

Concerns about the long-term safety of VDPHL01, an extended-release minoxidil, due to potential risks similar to Cantu syndrome, were raised, highlighting the lack of monitoring for chronic connective tissue changes. The conversation suggests that while the treatment may improve hair growth, it could lead to issues not detected in short-term trials.

community [Theory] Big Bald is deliberately delaying the cure indefinitely

348 upvotes 1 year ago

The conversation humorously suggests that the hair loss industry, referred to as "Big Bald," deliberately delays a cure to profit from ongoing treatments like minoxidil, finasteride, and dutasteride. Participants debate whether a cure would be more profitable than current treatments, with some suggesting that the industry prefers continuous treatments for sustained profit.

community What makes them say exercise doesn't increase hair loss?

in Research/Science 45 upvotes 1 year ago

Exercise has minimal impact on hair loss, with weight lifting slightly increasing DHT and cardio potentially decreasing it. Finasteride and dutasteride are effective treatments for managing hair loss, even for those who exercise regularly.

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