Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

    February 2022 in “ Acta Biomaterialia ”
    Eun Kyung Kim, Keum-Yong Seong, Da Sol Kim … Geun-Shik Lee
    Studysummary In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 37

    1. Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice Pharmaceutics · 2021
    2. Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial Dermatologic Therapy · 2020
    3. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020
    4. Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/β-Catenin Pathway in Dermal Papilla Cells Biomolecules & Therapeutics · 2020
    5. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    6. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019
    7. A Randomized Controlled, Single-Observer Blinded Study to Determine the Efficacy of Topical Minoxidil Plus Microneedling Versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia Journal of Cutaneous and Aesthetic Surgery · 2018
    8. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    9. Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation Archives of Dermatological Research · 2017
    10. Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice BMC Complementary and Alternative Medicine · 2017
    11. Guidelines on the Use of Finasteride in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2016
    12. Microneedle Applications in Improving Skin Appearance Experimental Dermatology · 2015
    13. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    14. The Ginsenosides of Panax Ginseng Promote Hair Growth via Similar Mechanism of Minoxidil Journal of Dermatological Science · 2015
    15. Hair Loss in Women: Diagnosis and Management of Nonscarring Diffuse Alopecias Clinical Obstetrics and Gynecology · 2014
    16. Erbium-Yttrium-Aluminum-Garnet Laser Irradiation Ameliorates Skin Permeation and Follicular Delivery of Antialopecia Drugs Journal of Pharmaceutical Sciences · 2014
    17. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    18. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    19. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    20. Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations British Journal of Dermatology · 2010
    21. In Vitro Skin Permeation of Monoolein Nanoparticles Containing Hydroxypropyl β-Cyclodextrin/Minoxidil Complex International Journal of Pharmaceutics · 2010
    22. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010
    23. Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2009
    24. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    25. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    26. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    27. Simultaneous Effects of Tocopheryl Polyethylene Glycol Succinate on Local Hair Growth Promotion and Systemic Absorption of Topically Applied Minoxidil in a Mouse Model International Journal of Pharmaceutics · 2005
    28. Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss Seminars in Plastic Surgery · 2005
    29. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    30. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    31. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    32. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    33. Whole Hair Follicle Culture Dermatologic clinics · 1996
    34. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    35. Quantitative Study of the Human Hair Follicle in Normal Scalp and Androgenetic Alopecia Journal of Cutaneous Pathology · 1993
    36. Expression of Extracellular Matrix in Hair Follicle Mesenchyme in Alopecia Areata British Journal of Dermatology · 1990
    37. Effect of Minoxidil on Pre- and Postconfluent Keratinocytes Journal of The American Academy of Dermatology · 1987

    Related research 9

    1. Effectiveness of Multimodality Therapy Using Minoxidil and Microneedling for the Treatment of Alopecia: A Systematic Review and Meta-Analysis 2023
    2. Pediatric Androgenetic Alopecia: An Updated Review Journal der Deutschen Dermatologischen Gesellschaft · 2023
    3. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    4. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    5. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    6. The Use of Trichoscopy to Assess the Efficacy of Topical Minoxidil 2% Solution in Patients with Female Pattern Hair Loss Zagazig university medical journal · 2019
    7. The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review PubMed · 2019
    8. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    9. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015