Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

February 2022 in “ Acta Biomaterialia ”

Eun Kyung Kim, Keum-Yong Seong, Da Sol Kim, Jea Sic Jeong, So Young Kim, Seungsoo Lee, Seung Hwan Yang, Geun-Shik Lee

minoxidil hyaluronic acid dissolving microneedles alopecia hair density hair follicle lengths dermal thickness hair dermal papilla cell proliferation cell migration cell aggregation Rogaine HA microneedles hair loss hair growth

TLDR Minoxidil-loaded hyaluronic acid microneedles can effectively increase hair growth and could be a promising treatment for hair loss.

The study investigated the use of minoxidil-loaded hyaluronic acid dissolving microneedles (HA-MNs) to alleviate hair loss in an alopecia animal model. The researchers found that HA-MNs increased hair density, hair follicle lengths, and dermal thickness in the alopecia-induced mice. HA provided a better environment for cell-cell adhesion and cellular functions, such as hair dermal papilla (HDP) cell proliferation, migration, and aggregation. The HA-MNs containing minoxidil were the most effective for hair growth. This study suggests that HA-MNs could be a promising treatment for hair loss.

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