Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial

December 2020 in “ Dermatologic Therapy ”

Barbara Pontes Cerqueira Uzel, Gustavo Henrique Soares Takano, Juliana Cabral Nunes Chartuni, Mariana Vicente Cesetti, Camila Fátima Biancardi Gavioli, André Moreira Lemes, Izelda Maria Carvalho Costa

minoxidil intradermal injections female androgenetic alopecia hair density hair thickness placebo-controlled trial Rogaine

Studysummary In this study, intradermal injections of 0.5% minoxidil significantly improved hair growth and volume in women with female androgenetic alopecia compared to a placebo, with a good safety profile reported.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A randomized, placebo-controlled trial found that intradermal injections with 0.5% minoxidil can effectively treat female androgenetic alopecia, resulting in increased hair density and thickness. The study involved 60 female participants and was well-tolerated with minimal side effects. The treatment was found to be safe and effective, but more research is needed to compare it to topical minoxidil and establish maintenance protocols.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research Hair Loss at Injection Sites of Mesotherapy for Alopecia

18 citations , February 2017 in “Journal of Cosmetic Dermatology”

This study reports that mesotherapy for androgenetic alopecia may paradoxically lead to hair loss and scarring, highlighting the need for improved regulation and monitoring of this treatment.

research Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia

24 citations , January 2017 in “International Journal of Trichology”

research Frontal Edema Due to Topical Application of 5% Minoxidil Solution Following Mesotherapy Injections

7 citations , January 2015 in “International Journal of Trichology”

This case report describes a woman who experienced frontal edema after topical minoxidil application following mesotherapy, noting that excessive absorption of minoxidil may cause localized vasodilatory side effects.

research Is TrichoScan a New Diagnostic Method for Diffuse Hair Loss?

2 citations , January 2014 in “Turkish Journal of Medical Sciences”

This study found that the TrichoScan software effectively differentiated between androgenetic alopecia and telogen effluvium in women with diffuse hair loss, aligning with clinical diagnoses.

Clinical and Histological Challenge in the Differential Diagnosis of Diffuse Alopecia: Female Androgenetic Alopecia, Telogen Effluvium, and Alopecia Areata – Part II

research Clinical and Histological Challenge in the Differential Diagnosis of Diffuse Alopecia: Female Androgenetic Alopecia, Telogen Effluvium, and Alopecia Areata – Part II

30 citations , November 2012 in “Anais Brasileiros De Dermatologia”

This review discusses chronic telogen effluvium and diffuse alopecia areata, providing clinical and diagnostic insights, but presents no new clinical findings.

research Clinical and Histological Challenge in the Differential Diagnosis of Diffuse Alopecia: Female Androgenetic Alopecia, Telogen Effluvium and Alopecia Areata – Part I

29 citations , October 2012 in “Anais Brasileiros De Dermatologia”

This review presents an objective analysis of female androgenetic alopecia, discussing clinical and dermoscopic examination approaches but reports no new clinical findings.

research Hair and Scalp Dermatoscopy

245 citations , March 2012 in “Journal of The American Academy of Dermatology”

This review discusses the dermoscopic features of common hair and scalp disorders and reports no new clinical results, aiming to assist dermatologists in diagnosing conditions like tinea capitis and alopecia areata.

research Value of Trichoscopy Versus Trichogram for Diagnosis of Female Androgenetic Alopecia

45 citations , January 2012 in “International Journal of Trichology”

This study reported that trichoscopy is a more effective diagnostic tool than the trichogram for early diagnosis of FAGA, regardless of hair shaft diversity cut-off levels.

research Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness

75 citations , December 2011 in “British Journal of Dermatology”

This review discusses female pattern hair loss, its psychological impact, and available treatments but provides no new clinical findings; the authors emphasize early intervention for better outcomes.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article discusses the development of an evidence-based guideline for treating androgenetic alopecia and reports no new research results.

research Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities

126 citations , January 2010 in “British Journal of Dermatology”

This study found that the prevalence of androgenetic alopecia in Chinese men and women was lower than in Caucasians and similar to that in Koreans.

research Occipital Involvement in Female Pattern Hair Loss: Histopathological Evidence

20 citations , August 2009 in “Journal of The European Academy of Dermatology and Venereology”

This study found that the occipital scalp is significantly involved in female pattern hair loss, with some patients showing clinically visible alopecia.

research Alopecia Secondary to Mesotherapy

49 citations , July 2009 in “Journal of the American Academy of Dermatology”

This report highlights two cases where patchy alopecia developed after mesotherapy for androgenetic alopecia, indicating potential risks associated with this treatment.

research Validation of TrichoScan Technology as a Fully-Automated Tool for Evaluation of Hair Growth Parameters

38 citations , May 2009 in “European journal of dermatology/EJD. European journal of dermatology”

This study found that the TrichoScan method for evaluating hair loss showed excellent correlation with manual marking and provided more consistent, reproducible results with less variability and operator error.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations , June 2006 in “British Journal of Dermatology”

This study found that as hair loss severity increased in women with female pattern hair loss, the number of vellus follicles also rose, indicating miniaturization of terminal hair follicles.

research TrichoScan: A Novel Tool for the Analysis of Hair Growth In Vivo

70 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study reports that the TrichoScan method effectively measures hair growth parameters and detected significant improvements in hair counts and thickness in men with androgenetic alopecia after finasteride treatment.

research Androgenetic Alopecia in Women

139 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Management of Androgenetic Alopecia

22 citations , May 2000 in “American Journal of Clinical Dermatology”

This review discusses treatment options for androgenetic alopecia in men and women, highlighting minoxidil and finasteride, without presenting new clinical findings.