Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia

    Adel Alsantali, Jerry Shapiro
    Image of study
    TLDR The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
    The 2009 document provides an in-depth analysis of androgenetic alopecia (AGA), detailing its genetic basis, pathogenesis, and treatment options. It identifies AGA as a polygenic condition with genetic associations on chromosomes 20p11 and 3q26. The document reports that dutasteride is more effective than finasteride in treating AGA, with a new topical liposomal finasteride formulation showing promise in vitro. It also reviews the only two approved medical therapies at the time: finasteride, which leads to hair regrowth in a significant percentage of patients and prevents further hair loss in most, and minoxidil, which has been associated with a substantial increase in hair regrowth. The document discusses the prevalence of AGA, its association with various diseases, and its psychological impact. It concludes by noting the importance of hair transplantation and the potential for gene therapy in future AGA management.
    Discuss this study in the Community →

    Research cited in this study

    52 / 52 results

    Related Community Posts Join

    6 / 1000+ results

      community Anyone else growing tired of the finasteride wars?

      in Finasteride/Dutasteride  169 upvotes 1 year ago
      The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

      community My good/bad experience with Creatine

      in Treatment  23 upvotes 2 weeks ago
      Creatine may cause increased hair shedding in some individuals, especially those with androgenetic alopecia (AGA), despite its physical performance benefits. Many users report stopping creatine to reduce hair loss, while others believe the effects are anecdotal or due to other factors like increased physical activity.

      community I have tried many treatments but it's getting worse. 23M.

      in Treatment  85 upvotes 3 months ago
      A 23-year-old male experiencing worsening hair loss has tried topical Minoxidil, Finasteride, Progesterone, Hydrocortisone butyrate, and Ketoconazole. He is considering switching to oral Finasteride due to concerns about side effects and lack of improvement.

    Related Research

    10 / 10 results