Sponsored Lecture 3: Updates on 5 Alpha-Reductase Inhibitors (5ARIs) for the Treatment of Male Pattern Hair Loss (MPHL)

January 2014 in “ 프로그램북(구 초록집) ”

Yang Won Lee

5-alpha reductase 5AR dihydrotestosterone testosterone 5AR isoenzymes type 1 5AR type 2 5AR minoxidil finasteride dutasteride androgenetic alopecia male pattern hair loss MPHL benign prostatic hyperplasia DHT Rogaine Propecia Avodart BPH

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This article reviews updates on 5 alpha-reductase inhibitors for treating male pattern hair loss and presents no new clinical findings; the author aims to enhance understanding of these therapies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Male pattern hair loss (MPHL), affecting about 50% of both sexes, is linked to the enzyme 5-alpha reductase (5AR), which converts testosterone to dihydrotestosterone, a key factor in hair loss. There are three isoenzymes of 5AR, with type 1 found in skin and hair follicles, and type 2 in male genitalia and hair follicles. Treatments include topical minoxidil and oral finasteride, a type 2 5AR inhibitor, which significantly improves hair growth and slows hair loss. Dutasteride, a dual inhibitor of type 1 and 2 5AR, has shown efficacy in treating benign prostatic hyperplasia and androgenetic alopecia, with a 2009 study in Korea demonstrating significant hair growth improvement. The lecture aimed to provide updates on 5AR inhibitors for better understanding and treatment of MPHL.

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