Male Androgenetic Alopecia

    January 2012 in “ Human health handbooks
    Salvador Arias-Santiago, Agustín Buendía-Eisman, María Teresa Gutiérrez-Salmerón, S. Serrano-Ortega
    TLDR Male pattern baldness is mainly caused by genetics and hormones, treatable with minoxidil and finasteride.
    Androgenetic alopecia (AGA) was the most common hair loss disorder in men, primarily influenced by genetic factors and the action of androgens, leading to the transformation of terminal hairs into vellus hairs. It was characterized by progressive, non-scarring hair loss due to follicular miniaturization, with a distinct pattern distribution. Additional factors such as chronic inflammation and hormones like aldosterone, insulin, and vitamin D were also implicated in its pathogenesis. Diagnosis was typically based on clinical history and examination, with tools like dermoscopy and trichoscan aiding the process. Minoxidil and finasteride were the main treatments, with minoxidil's mechanism possibly linked to increased blood flow and finasteride acting as a type II 5-α-reductase inhibitor. While AGA did not directly affect physical health, it could indicate other health issues or cause significant psychosocial effects.
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