Physiology and Medical Treatments for Alopecia

    Tymon Tai, Amit Kochhar
    Studysummary This abstract explains that androgenetic alopecia, a common hair loss disorder influenced by genetics and hormones like dihydrotestosterone, has FDA-approved treatments including minoxidil, finasteride, and photolaser therapy, but its genetic basis and susceptibility to environmental factors remain complex.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 57

    1. Understanding and Addressing Hair Disorders in Transgender Individuals American Journal of Clinical Dermatology · 2018
    2. Systematic Review of Low-Level Laser Therapy for Adult Androgenic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    3. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    4. Platelet-Rich Plasma for the Aesthetic Surgeon Facial Plastic Surgery · 2017
    5. Genetics and Other Factors in the Etiology of Female Pattern Hair Loss Experimental Dermatology · 2017
    6. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    7. Androgenetic Alopecia: A Review Endocrine · 2017
    8. Dermatologic Care of the Transgender Patient International Journal of Women's Dermatology · 2016
    9. Testosterone Therapy for Transgender Men: Effects and Safety The Lancet Diabetes & Endocrinology · 2016
    10. Scalp Hair Regrowth in Hormone-Treated Transgender Woman Transgender health · 2016
    11. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    12. Platelet-Rich Plasma for Androgenetic Alopecia Dermatologic Surgery · 2014
    13. Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period Journal of Cutaneous and Aesthetic Surgery · 2014
    14. Nonsurgical Therapy for Hair Loss Facial Plastic Surgery Clinics of North America · 2013
    15. Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss Journal of Dermatological Science · 2013
    16. No Genetic Support for a Contribution of Prostaglandins to the Etiology of Androgenetic Alopecia British Journal of Dermatology · 2013
    17. Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments Dermatologic Clinics · 2012
    18. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    19. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    20. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    21. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    22. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    23. A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2011
    24. Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia British Journal of Dermatology · 2011
    25. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    26. 5 mg/Day Finasteride Treatment for Normoandrogenic Asian Women with Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2010
    27. Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome British Journal of Dermatology · 2010
    28. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    29. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    30. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    31. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    32. Dutasteride Improves Male Pattern Hair Loss in a Randomized Study in Identical Twins Journal of Cosmetic Dermatology · 2007
    33. Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia Human Genetics · 2007
    34. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    35. Finasteride Treatment of Female Pattern Hair Loss Archives of Dermatology · 2006
    36. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    37. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    38. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    39. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    40. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    41. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002
    42. Effects of Minoxidil 2% vs. Cyproterone Acetate Treatment on Female Androgenetic Alopecia: A Controlled, 12-Month Randomized Trial British Journal of Dermatology · 2002
    43. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002
    44. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    45. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    46. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    47. Effects of Sex Steroid Deprivation and Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2000
    48. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women Journal of Investigative Dermatology Symposium Proceedings · 1999
    49. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    50. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    51. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    52. Finasteride The New England Journal of Medicine · 1994
    53. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    54. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992
    55. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992
    56. Use of Topical Minoxidil as a Possible Adjunct to Hair Transplant Surgery Journal of The American Academy of Dermatology · 1987
    57. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977

    Related research 10

    1. Pediatric Androgenetic Alopecia: An Updated Review Journal der Deutschen Dermatologischen Gesellschaft · 2023
    2. Pharmacological Therapeutics in Androgenetic Alopecia Journal of The Korean Medical Association · 2020
    3. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    4. Characteristics of Korean Scalp Hair and Male Pattern Baldness Journal of The Korean Medical Association · 2013
    5. Types of Hair Loss and Treatment Options, Including the Novel Low-Level Light Therapy and Its Proposed Mechanism Southern Medical Journal · 2010
    6. Principles and Techniques of Surgical Hair Restoration 2007
    7. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    8. Current Management of Androgenetic Alopecia in Men PubMed · 1999
    9. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    10. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992