No Genetic Support for a Contribution of Prostaglandins to the Etiology of Androgenetic Alopecia

March 2013 in “ British Journal of Dermatology ”

Stefanie Heilmann, Dale R. Nyholt, Felix F. Brockschmidt, Axel M. Hillmer, Christoph Herold, Thomas Becker, Nicholas G. Martin, Markus M. Nöthen

androgenetic alopecia prostaglandins hair follicles AGA

Studysummary No genetic link between prostaglandins and hair loss found.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study found no genetic evidence to support the role of prostaglandins in the development of androgenetic alopecia (AGA), despite previous observations of differences in prostaglandin expression between balding and nonbalding hair follicles. The study was conducted by the MAAN consortium and was supported by the Life & Brain GmbH and the Alfried Krupp von Bohlen und Halbach-Stiftung.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations , May 2012 in “PLOS Genetics”

This study found that early-onset androgenetic alopecia in individuals of European ancestry is significantly associated with increased odds of Parkinson's disease and is influenced by specific genetic loci, including some linked to reduced fertility.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

51 citations , November 2011 in “British Journal of Dermatology”

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.