Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix

The document from November 1, 2015, highlights the impact of testosterone and prostaglandins on hair function and the development of androgenetic alopecia (AGA). It suggests that testosterone may negatively affect the Wnt signaling pathway, which is crucial for hair function, while prostaglandin D2 (PGD₂), found in higher levels in the scalp of men with AGA, could be responsible for this inhibition. Conversely, prostaglandin F2α (PGF₂α) is associated with promoting eyelash growth. The study reveals that prostaglandins can have varying effects on hair growth, with the enzyme responsible for PGD2 production being stimulated by testosterone. The research underscores the importance of understanding the interaction between androgens, β-catenin, and Wnt signaling in hair follicles to better grasp the pathology of androgen-related skin conditions. The research received funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the authors have stated no conflicts of interest.