Precision Therapeutics in Non-Scarring Alopecia: A Systemic Genomic and Pathway-Based Framework for Targeted Interventions

    December 2025 in “ ADMET & DMPK ”
    Rinky Kapoor, Depti Bellani, Raji Patil … Debraj Shome
    Studysummary This review synthesizes recent research to propose a precision framework for treating androgenetic alopecia and alopecia areata based on genetic insights and pathway biology, highlighting the roles of androgen-receptor signaling, immune dysregulation, and emerging therapies like regenerative medicine and AI-assisted diagnostics.
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    Research cited in this study 87

    1. Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization Nutrients · 2025
    2. Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies Stem Cell Research & Therapy · 2025
    3. Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases Stem Cell Reviews and Reports · 2025
    4. Comprehensive Review on Hair Loss and Restorative Techniques: Advances in Diagnostic, Artistry, and Surgical Innovation Cureus · 2025
    5. Evaluation of the Efficacy of a Biomimetic Peptide Solution for Rejuvenation of Donor Scalp and as Storage Media for Hair Follicle Grafts During FUE Hair Transplantation Journal of Cosmetic and Laser Therapy · 2025
    6. Identifying Effective Immune Biomarkers in Alopecia Areata Diagnosis Based on Machine Learning Methods BMC Medical Informatics and Decision Making · 2025
    7. Integrating Psychological Support and Topical Therapy for the Effective Management of Stress-Induced Alopecia Areata: A Case Report Cureus · 2025
    8. A Review on Androgenic Alopecia: Etiology, Pathogenesis, Pharmacological and Non-Pharmacological Treatment Approaches Ain Shams Medical Journal · 2024
    9. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    10. Effectiveness of Minimally Invasive Injectable Modalities in the Management of Androgenetic Alopecia Among Adults—A Systematic Review Journal of Cosmetic Dermatology · 2024
    11. Hair Growth Promoting Effects of Solubilized Sturgeon Oil and Its Correlation with the Gut Microbiome Pharmaceuticals · 2024
    12. Retracted: Interleukin-33 Links Asthma to Alopecia Areata: Mendelian Randomization and Mediation Analysis Skin Research and Technology · 2024
    13. Enhancing Hair Regeneration: Recent Progress in Tailoring Nano-Structured Lipid Carriers Through Surface Modification Strategies ADMET & DMPK · 2024
    14. Small Molecule Agents Against Alopecia: Potential Targets And Related Pathways European Journal of Medicinal Chemistry · 2024
    15. Association Between PITX2 Polymorphism And Androgenetic Alopecia In The Indian Population Indian Journal of Dermatology Venereology and Leprology · 2024
    16. 1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways The Journal of Nutritional Biochemistry · 2024
    17. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    18. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets Molecules/Molecules online/Molecules annual · 2024
    19. Causal Effects of Genetically Determined Metabolites on Androgenetic Alopecia: A Two-Sample Mendelian Randomization Analysis Skin research and technology · 2024
    20. Utilizing SNP Association Analysis as a Prospective Approach for Personalizing Androgenetic Alopecia Treatment Dermatology and therapy (Internet) · 2024
    21. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    22. Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata Journal of Investigative Dermatology · 2024
    23. Evaluation of Oxidative Stress Markers in Androgenetic Alopecia Patients Benha Journal of Applied Sciences · 2023
    24. Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia 2023
    25. Gut Microbiome, Metabolome and Alopecia Areata Frontiers in microbiology · 2023
    26. A Newer Approach in the Treatment of Seborrheic Dermatitis With QR678 and QR678 Neo: A Prospective Pilot Study Journal of Cosmetic Dermatology · 2023
    27. Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways International journal of molecular sciences · 2023
    28. Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review Genes · 2023
    29. Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases Research Square (Research Square) · 2023
    30. Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms Precision clinical medicine · 2023
    31. Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    32. Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study Frontiers in Immunology · 2023
    33. Alopecia Areata: A Review of the Genetic Variants and Immunodeficiency Disorders Associated with Alopecia Areata Skin Appendage Disorders · 2023
    34. Application of LncRNA-miRNA-mRNA CeRNA Network Analysis in the Treatment of Androgenic Alopecia PubMed · 2022
    35. Anxiety, Depression, and Quality of Life in Children and Adults With Alopecia Areata: A Systematic Review and Meta-Analysis Frontiers in Medicine · 2022
    36. The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth The Korean Journal of Physiology and Pharmacology · 2022
    37. Evaluation of Efficacy of Derma Roller Sizes vs Topical Application for Administration of QR678 Neo Hair Regrowth Formulation in the Treatment of Androgenetic Alopecia Journal of Cosmetic Dermatology · 2022
    38. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    39. Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets Experimental Dermatology · 2022
    40. Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia Pharmaceutics · 2022
    41. Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells Frontiers in Genetics · 2022
    42. Evaluation of the Safety and Effectiveness of Intradermal Administration of QR678 Neo Hair Growth Factor Formulation: A Phase-IV, Open-Label, Single-Arm Multi-Ethnicity Clinical Trial Journal of Cosmetic Dermatology · 2022
    43. Androgenetic Alopecia From A to Z Springer eBooks · 2022
    44. Efficacy of QR678 Neo Hair Growth Factor Formulation for the Treatment of Hair Loss in COVID-19-Induced Persistent Telogen Effluvium: A Prospective, Clinical, Single-Blind Study Journal of Cosmetic Dermatology · 2021
    45. Effectiveness of QR678 and QR678 Neo with Intralesional Corticosteroid vs. Intralesional Corticosteroid Alone in the Treatment of Alopecia Areata – A Randomized, Comparative, Prospective Study Journal of Cosmetic Dermatology · 2021
    46. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    47. Finasteride for Hair Loss: A Review Journal of Dermatological Treatment · 2021
    48. Androgenetic Alopecia and COVID-19: A Review of the Hypothetical Role of Androgens Dermatologic Therapy · 2021
    49. Transcription Factor FOXC1 Positively Regulates SFRP1 Expression in Androgenetic Alopecia Experimental Cell Research · 2021
    50. Current Insight Into the Functions of MicroRNAs in Common Human Hair Loss Disorders: A Mini Review Human Cell · 2021
    51. Comparison of QR 678 and QR 678 Neo as Monotherapy and Combination Therapy with 5% Minoxidil Solution and Oral Finasteride in the Treatment of Male Androgenetic Alopecia—Which Is Better? Journal of Cosmetic Dermatology · 2021
    52. Evaluation of Efficacy of Intradermal Injection Therapy vs Derma Roller Application for Administration of QR678 Neo Hair Regrowth Formulation for the Treatment of Androgenetic Alopecia—A Prospective Study Journal of Cosmetic Dermatology · 2021
    53. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021
    54. MiRNA Microarray Profiling in Patients with Androgenic Alopecia and the Effects of miR-133b on Hair Growth Experimental and Molecular Pathology · 2020
    55. Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia JAMA Dermatology · 2020
    56. Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia International Journal of Molecular Sciences · 2020
    57. Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients Journal of Dermatological Science · 2020
    58. Evaluation of Efficacy of QR 678 and QR678 Neo Hair Growth Factor Formulation for the Treatment of Female Pattern Alopecia in Patients with PCOS—A Prospective Study Journal of Cosmetic Dermatology · 2020
    59. Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2020
    60. QR678 and QR678 Neo Hair Growth Formulations: A Cellular Toxicity and Animal Efficacy Study Plastic and reconstructive surgery. Global open · 2020
    61. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    62. QR 678 and QR678 Neo vs PRP—A Randomized, Comparative, Prospective Study Journal of Cosmetic Dermatology · 2020
    63. A Perspective on Predictive Markers of Alopecia Archives of Medicine and Health Sciences · 2020
    64. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    65. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    66. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    67. Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions Expert Opinion on Therapeutic Targets · 2018
    68. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    69. Intradermal Injections of a Hair Growth Factor Formulation for Enhancement of Human Hair Regrowth: Safety and Efficacy Evaluation in a First-in-Man Pilot Clinical Study Journal of Cosmetic and Laser Therapy · 2018
    70. Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth The Korean Journal of Physiology and Pharmacology · 2018
    71. Androgenetic Alopecia: A Review Endocrine · 2017
    72. Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature Journal of Dermatological Treatment · 2016
    73. Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis British Journal of Dermatology · 2014
    74. Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer Journal of The European Academy of Dermatology and Venereology · 2014
    75. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    76. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    77. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    78. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    79. APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex Nature · 2010
    80. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    81. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    82. Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia Human Genetics · 2007
    83. Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis Journal of Dermatological Science · 2004
    84. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    85. Treatment of Hair Loss The New England Journal of Medicine · 1999
    86. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    87. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998