Studysummary This review discusses the increasing prevalence of alopecia in younger populations and outlines the need for better understanding its pathogenesis to develop effective treatments. It also examines current FDA-approved drugs and emerging small molecule compounds with potential anti-alopecia effects.
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Research cited in this study 143
- The Efficacy and Safety of Oral Spironolactone in the Treatment of Female Pattern Hair Loss: A Systematic Review and Meta-Analysis Cureus · 2023
- Ritlecitinib: First Approval Drugs · 2023
- Janus Kinase Inhibitors For Alopecia Areata JAMA network open · 2023
- PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023
- Androgenetic Alopecia: Therapy Update Drugs · 2023
- Traction Alopecia JAMA dermatology · 2023
- Medications Affecting the Insulin-Like Growth Factor 1/Growth Hormone Axis, Including Teprotumumab, Somatostatin Analogs, and Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies, Are Associated With Elevated Reporting Odds of Alopecia in Women: A Pharmacovigilance Study Journal of The American Academy of Dermatology · 2023
- Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
- The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2023
- Low-Dose Oral Minoxidil Improves Hair Density in Traction Alopecia Journal of The American Academy of Dermatology · 2023
- CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 Cells · 2023
- The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
- Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells Nutrients · 2022
- The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
- Enhancement of Hair Growth Through Stimulation of Hair Follicle Stem Cells by Prostaglandin E2 Collagen Matrix Experimental cell research · 2022
- Alopecia Areata: Case Report and Review of Pathophysiology and Treatment with JAK Inhibitors Journal of autoimmunity · 2022
- Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
- Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
- An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
- Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
- Exploring the Effects of Chinese Herbal Ingredients on the Signaling Pathway of Alopecia and Screening Effective Compounds Journal of Ethnopharmacology · 2022
- Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
- Modulation of Hair Growth Promoting Effect by Natural Products Pharmaceutics · 2021
- The Inflammatory Component of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
- Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
- A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
- Topical Dapsone for Folliculitis Decalvans: A Retrospective Cohort Study Journal of the American Academy of Dermatology · 2021
- Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
- Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study Journal of The American Academy of Dermatology · 2021
- Micro-Current Stimulation Has Potential Effects of Hair Growth Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model International Journal of Molecular Sciences · 2021
- Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
- A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results Journal of the American Academy of Dermatology · 2021
- Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss Journal of Medicinal Chemistry · 2021
- Telogen Effluvium: A Review of the Science and Current Obstacles Journal of Dermatological Science · 2021
- Low-Dose Oral Minoxidil Improves Global Hair Density and Length in Children with Loose Anagen Hair Syndrome British Journal of Dermatology · 2020
- Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
- Hair Loss Treatment Information on Facebook: Content Analysis and Comparison with Other Online Sources Journal of Cosmetic Dermatology · 2020
- Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
- Changing Trends in Surgical Hair Restoration: Use of Google Trends and the ISHRS Practice Census Survey Journal of Cosmetic Dermatology · 2020
- Female Pattern Hair Loss in Men: A Distinct Clinical Variant of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2020
- The Shifting Preferences of Patients and Physicians in Nonsurgical Hair Loss Treatment Journal of Cosmetic Dermatology · 2020
- Analysis of YouTube Hair Loss Treatment Information: What Makes for Engaging Content? Dermatologic Therapy · 2020
- Female Pattern Hair Loss: A Comprehensive Review Dermatologic Therapy · 2020
- The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
- Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
- Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
- Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
- PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
- JAK Inhibition in the Treatment of Alopecia Areata: A Promising New Dawn? Expert review of clinical pharmacology · 2019
- PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
- Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019
- Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
- Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
- The Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata: A Systematic Review Dermatologic therapy · 2019
- An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
- The Balance of BMP6 and WNT10B Regulates the Telogen-Anagen Transition of Hair Follicles Cell Communication and Signaling · 2019
- Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
- Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells in Vivo · 2019
- Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities Pharmacology & Therapeutics · 2018
- Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride Dermatologic Therapy · 2018
- Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study International Journal of Dermatology · 2018
- Updates in Therapeutics for Folliculitis Decalvans: A Systematic Review with Evidence-Based Analysis Journal of the American Academy of Dermatology · 2018
- Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
- Folliculitis Decalvans: Effectiveness of Therapies and Prognostic Factors in a Multicenter Series of 60 Patients with Long-Term Follow-Up Journal of The American Academy of Dermatology · 2018
- Loose Anagen Hair Syndrome: A Case Study of a 6-Year-Old Girl The journal of pediatrics/The Journal of pediatrics · 2018
- Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
- Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
- Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
- Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
- Hair Loss: Common Causes and Treatment PubMed · 2017
- Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia Skin appendage disorders · 2017
- Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
- Alopecia Areata: A Comprehensive Review of Pathogenesis and Management Clinical Reviews in Allergy & Immunology · 2017
- Regulating Hair Follicle Stem Cells Immunity · 2017
- Androgenetic Alopecia: A Review Endocrine · 2017
- Icariin Promotes Mouse Hair Follicle Growth by Increasing Insulin-Like Growth Factor 1 Expression in Dermal Papillary Cells Clinical and Experimental Dermatology · 2017
- Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice BMC Complementary and Alternative Medicine · 2017
- Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles Pharmacological Reports · 2017
- PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017
- Trichotillomania: Differences From OCD and Treatment Approaches American Journal of Psychiatry · 2016
- Minoxidil Improved Hair Density in an Asian Girl with Short Anagen Syndrome: A Case Report and Review of Literature International Journal of Dermatology · 2016
- Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
- Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
- The Involvement of Androgens in Human Hair Growth American journal of biomedical sciences · 2015
- Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
- The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology Experimental Dermatology · 2015
- Erosive Pustular Dermatosis of the Scalp Following Topical Latanoprost for Androgenetic Alopecia Dermatologic Therapy · 2015
- A Hospital-Based Study to Determine Causes of Diffuse Hair Loss in Women Journal of Clinical and Diagnostic Research · 2015
- Dermatoscopic Features of Central Centrifugal Cicatricial Alopecia Journal of The American Academy of Dermatology · 2014
- Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling PloS one · 2014
- Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice ISRN Pharmacology (Print) · 2014
- The Inhibitory Effect of Scutellaria Baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia Planta Medica · 2014
- Health Status, Coping Strategies, and Alexithymia in Subjects with Androgenetic Alopecia American Journal of Clinical Dermatology · 2013
- Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
- Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
- Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin · 2013
- Successful Treatment of Temporal Triangular Alopecia with Topical Minoxidil Annals of Dermatology · 2013
- Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
- Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
- British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
- Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
- Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
- Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B Annals of Dermatology · 2012
- Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
- Erosive Pustular Dermatosis of the Scalp from Topical Minoxidil 5% Solution International Journal of Dermatology · 2011
- Temporal Triangular Alopecia: Trichoscopic Diagnosis The Journal of Dermatology · 2011
- Abnormal Inner Root Sheath of the Hair Follicle in the Loose Anagen Hair Syndrome: An Ultrastructural Study Journal of the American Academy of Dermatology · 2010
- Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells BMB Reports · 2010
- Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
- Involvement of Scalp and Nails in Lupus Erythematosus Lupus · 2010
- Short Anagen Syndrome in an African American Woman Journal of The American Academy of Dermatology · 2010
- Temporal Triangular Alopecia and a Review of 52 Past Cases Journal of Dermatology · 2010
- Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist Archives of dermatology · 2009
- Discoid Lupus Erythematosus Presenting with Cysts, Comedones, and Cicatricial Alopecia on the Scalp Journal of the American Academy of Dermatology · 2009
- Central Centrifugal Cicatricial Alopecia: Past, Present, and Future Journal of The American Academy of Dermatology · 2009
- Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
- Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
- The Role of Scalp Dermoscopy in the Diagnosis of Alopecia Areata Incognita Journal of The American Academy of Dermatology · 2008
- Keratosis Follicularis Spinulosa Decalvans in a Family Journal of the American Academy of Dermatology · 2008
- Keratosis Follicularis Spinulosa Decalvans Associated With Acne Keloidalis Nuchae And Tufted Hair Folliculitis American Journal of Clinical Dermatology · 2008
- The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro Biological & Pharmaceutical Bulletin · 2007
- Novel 5α-Reductase Inhibitors: Synthesis, Structure-Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005
- Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
- Short Anagen Syndrome Journal of The American Academy of Dermatology · 2005
- A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
- Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
- Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
- Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings · 2003
- In Vivo Promoted Growth of Mice Hair Follicles by the Controlled Release of Growth Factors Biomaterials · 2003
- Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth The FASEB journal · 2002
- A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
- Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
- Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Treatment with Finasteride, 1 mg, Daily Journal of The American Academy of Dermatology · 2002
- Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
- Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
- Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000
- Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000
- Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000
- Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
- Management of Androgenetic Alopecia American Journal of Clinical Dermatology · 2000
- Treatment of Hair Loss The New England Journal of Medicine · 1999
- Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course Journal of Dermatological Treatment · 1997
- The History of the Development of Minoxidil Clinics in Dermatology · 1988