Exploring the Effects of Chinese Herbal Ingredients on the Signaling Pathway of Alopecia and Screening Effective Compounds

    April 2022 in “ Journal of Ethnopharmacology
    Dou Jinjin, Zhang Zhi-Ming, Xu Xianrong, Zhang Xiwu
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    TLDR Chinese herbal medicine can help treat hair loss by promoting hair growth and preventing cell death, maintaining a balance between hair growth and loss.
    The document reviews the effects of Chinese herbal ingredients on the signaling pathway of alopecia and screens effective herbal compounds for treating hair loss. Alopecia, or hair loss, is a condition that can be caused by various factors, including genetics, diet, alcohol abuse, and mental stress. The study highlights that traditional Chinese medicine (TCM), particularly those with glycoside active ingredients, has shown efficacy in preventing and treating hair loss and promoting hair regrowth. The research direction of Chinese medicine is mainly to promote the early entry of hair follicle cells into the anagen phase or to inhibit the apoptosis of hair follicle cells. The paper concludes that Chinese herbal medicine treats hair loss by targeting and regulating hair growth-promoting factors and preventing apoptosis, thus maintaining the dynamic balance between hair growth and hair loss.
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